biostudies-literatureUnknown4(22)Sobieski CPericardial decompression syndrome (PDS) is a potentially fatal disorder of left ventricular function that sometimes occurs after drainage of a pericardial effusion for cardiac tamponade. Patients at risk for PDS are difficult to identify. Here, we report 2 cases where PDS developed after drainage of effusions that had been present for years, suggesting that patients with chronic effusions are at higher risk for PDS. (<b>Level of Difficulty: Advanced.</b>).JACC. Case reports1515-1521https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700074biostudies-literaturePericardial Decompression Syndrome After Drainage of Chronic Pericardial Effusions.PMC9700074Goyal NChang LHerner MMcGarry TJKhor LLBieging ESobieski CfalsePericardial Decompression Syndrome After Drainage of Chronic Pericardial Effusions.Pericardial decompression syndrome (PDS) is a potentially fatal disorder of left ventricular function that sometimes occurs after drainage of a pericardial effusion for cardiac tamponade. Patients at risk for PDS are difficult to identify. Here, we report 2 cases where PDS developed after drainage of effusions that had been present for years, suggesting that patients with chronic effusions are at higher risk for PDS. (<b>Level of Difficulty: Advanced.</b>).2022-01-01T00:00:00Z2022 Nov2025-04-19T21:41:27.435Z2025-04-19T21:41:27.435ZS-EPMC97000743644417610.1016/j.jaccas.2022.08.023