biostudies-literatureUnknown4(22)Sharma VWe present a case of a 75-year-old man who developed an acute left atrial appendage thrombus immediately following mitral valve transcatheter edge to edge repair despite adequate intraprocedural anticoagulation. The patient was managed with enoxaparin to warfarin bridging with no obvious thromboembolic events on follow-up. Attention to anticoagulation is important to reduce thromboembolic risk during mitral valve transcatheter edge to edge repair. (<b>Level of Difficulty: Intermediate.</b>).JACC. Case reports1475-1479https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700075biostudies-literatureAcute Left Atrial Appendage Thrombus Formation During Transcatheter Mitral Valve Edge-to-Edge Repair.PMC9700075El Accaoui RNHorwitz PASharma VRossen JDfalseAcute Left Atrial Appendage Thrombus Formation During Transcatheter Mitral Valve Edge-to-Edge Repair.We present a case of a 75-year-old man who developed an acute left atrial appendage thrombus immediately following mitral valve transcatheter edge to edge repair despite adequate intraprocedural anticoagulation. The patient was managed with enoxaparin to warfarin bridging with no obvious thromboembolic events on follow-up. Attention to anticoagulation is important to reduce thromboembolic risk during mitral valve transcatheter edge to edge repair. (<b>Level of Difficulty: Intermediate.</b>).2022-01-01T00:00:00Z2022 Nov2025-04-22T09:53:24.504Z2025-04-05T23:17:14.831ZS-EPMC97000753644418110.1016/j.jaccas.2022.08.046