{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(4)"],"submitter":["Shi G"],"pubmed_abstract":["Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved in the formation and development of memory, and that DNA methylation plays a key role in the regulation of learning and memory. To investigate the role of DNA hypomethylation in cerebral ischemia/reperfusion injury, in this study, we established a rat model of cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery and then treated the rats with intraperitoneal 5-aza-2'-deoxycytidine, an inhibitor of DNA methylation. Our results showed that 5-aza-2'-deoxycytidine markedly improved the neurological function, and cognitive, social and spatial memory abilities, and dose-dependently increased the synaptic density and the expression of SYP a"],"journal":["Neural regeneration research"],"pagination":["863-868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700107"],"repository":["biostudies-literature"],"pubmed_title":["DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury."],"pmcid":["PMC9700107"],"pubmed_authors":["Jian LY","Fan XY","Feng J","Shi G"],"additional_accession":[]},"is_claimable":false,"name":"DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury.","description":"Cerebral ischemia/reperfusion injury impairs learning and memory in patients. Studies have shown that synaptic function is involved in the formation and development of memory, and that DNA methylation plays a key role in the regulation of learning and memory. To investigate the role of DNA hypomethylation in cerebral ischemia/reperfusion injury, in this study, we established a rat model of cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery and then treated the rats with intraperitoneal 5-aza-2'-deoxycytidine, an inhibitor of DNA methylation. Our results showed that 5-aza-2'-deoxycytidine markedly improved the neurological function, and cognitive, social and spatial memory abilities, and dose-dependently increased the synaptic density and the expression of SYP a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-27T19:11:08.341Z","creation":"2025-02-19T03:23:23.799Z"},"accession":"S-EPMC9700107","cross_references":{"pubmed":["36204855"],"doi":["10.4103/1673-5374.353494"]}}