{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Castle JR"],"funding":["NIDDK NIH HHS"],"pagination":["892-897"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(12)"],"pubmed_abstract":["<b><i>Introduction:</i></b> DailyDose is a decision support system designed to provide real-time dosing advice and weekly insulin dose adjustments for adults living with type 1 diabetes using multiple daily insulin injections. <b><i>Materials and Methods:</i></b> Twenty-five adults were enrolled in this single-arm study. All participants used Dexcom G6 for continuous glucose monitoring, InPen for short-acting insulin doses, and Clipsulin to track long-acting insulin doses. Participants used DailyDose on an iPhone for 8 weeks. The primary endpoint was % time in range (TIR) comparing the 2-week baseline to the final 2-week period of DailyDose use. <b><i>Results:</i></b> There were no significant differences between TIR or other glycemic metrics between the baseline period compared to final 2-week period of DailyDose use. TIR significantly improved by 6.3% when more than half of recommendations were accepted and followed compared with 50% or fewer recommendations (95% CI 2.5%-10.1%, <i>P</i> = 0.001). <b><i>Conclusions:</i></b> Use of DailyDose did not improve glycemic outcomes compared to the baseline period. In a post hoc analysis, accepting and following recommendations from DailyDose was associated with improved TIR. <b><i>Clinical Trial Registration Number:</i></b> NCT04428645."],"journal":["Diabetes technology & therapeutics"],"pubmed_title":["Assessment of a Decision Support System for Adults with Type 1 Diabetes on Multiple Daily Insulin Injections."],"pmcid":["PMC9700374"],"funding_grant_id":["R01 DK120367","F30 DK128914"],"pubmed_authors":["Wilson LM","Espinoza AZ","Jacobs PG","Kushner T","Castle JR","Oganessian SM","Winters-Stone K","Young GM","Tyler NS","Hilts WW","Pinsonault J","Branigan DL","Ramsey K","Cafazzo JA","Dodier RH","Eom JH","Mosquera-Lopez CM","Gabo VB","Youssef JE"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of a Decision Support System for Adults with Type 1 Diabetes on Multiple Daily Insulin Injections.","description":"<b><i>Introduction:</i></b> DailyDose is a decision support system designed to provide real-time dosing advice and weekly insulin dose adjustments for adults living with type 1 diabetes using multiple daily insulin injections. <b><i>Materials and Methods:</i></b> Twenty-five adults were enrolled in this single-arm study. All participants used Dexcom G6 for continuous glucose monitoring, InPen for short-acting insulin doses, and Clipsulin to track long-acting insulin doses. Participants used DailyDose on an iPhone for 8 weeks. The primary endpoint was % time in range (TIR) comparing the 2-week baseline to the final 2-week period of DailyDose use. <b><i>Results:</i></b> There were no significant differences between TIR or other glycemic metrics between the baseline period compared to final 2-week period of DailyDose use. TIR significantly improved by 6.3% when more than half of recommendations were accepted and followed compared with 50% or fewer recommendations (95% CI 2.5%-10.1%, <i>P</i> = 0.001). <b><i>Conclusions:</i></b> Use of DailyDose did not improve glycemic outcomes compared to the baseline period. In a post hoc analysis, accepting and following recommendations from DailyDose was associated with improved TIR. <b><i>Clinical Trial Registration Number:</i></b> NCT04428645.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-29T00:47:01.541Z","creation":"2025-04-05T19:03:23.512Z"},"accession":"S-EPMC9700374","cross_references":{"pubmed":["35920839"],"doi":["10.1089/dia.2022.0252"]}}