{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(11)"],"submitter":["Suzuki S"],"pubmed_abstract":["<b><i>Background:</i></b> We previously found low thyrotropin (TSH) levels in children and adolescents with thyroid nodules, including papillary thyroid cancer, although it is generally accepted that high TSH levels are a risk factor for formation and growth of thyroid nodules in adults. To clarify the reasons for the discrepancy, we precisely analyzed the features of pituitary-thyroid hormone (TH) actions in children and adolescents with or without nodules at different ages. <b><i>Methods:</i></b> Among the 4955 participants who participated in a second screening by thyroid ultrasound examination in the Fukushima Health Management Survey, 721 and 2849 euthyroid participants aged 6-20 years without or with nodules, including thyroid cancer, were selected for evaluation of TH regulation. Th"],"journal":["Thyroid : official journal of the American Thyroid Association"],"pagination":["1316-1327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700379"],"repository":["biostudies-literature"],"pubmed_title":["Possible Association Between Thyroid Nodule Formation and Developmental Alterations in the Pituitary-Thyroid Hormone Axis in Children and Adolescents: The Fukushima Health Management Survey."],"pmcid":["PMC9700379"],"pubmed_authors":["Kamiya K","Suzuki S","Ohira T","Yokoya S","Ohto H","Iwadate M","Matsuzuka T","Yasumura S","Furuya F","Shimura H"],"additional_accession":[]},"is_claimable":false,"name":"Possible Association Between Thyroid Nodule Formation and Developmental Alterations in the Pituitary-Thyroid Hormone Axis in Children and Adolescents: The Fukushima Health Management Survey.","description":"<b><i>Background:</i></b> We previously found low thyrotropin (TSH) levels in children and adolescents with thyroid nodules, including papillary thyroid cancer, although it is generally accepted that high TSH levels are a risk factor for formation and growth of thyroid nodules in adults. To clarify the reasons for the discrepancy, we precisely analyzed the features of pituitary-thyroid hormone (TH) actions in children and adolescents with or without nodules at different ages. <b><i>Methods:</i></b> Among the 4955 participants who participated in a second screening by thyroid ultrasound examination in the Fukushima Health Management Survey, 721 and 2849 euthyroid participants aged 6-20 years without or with nodules, including thyroid cancer, were selected for evaluation of TH regulation. Th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T19:38:22.937Z","creation":"2025-04-04T19:38:22.937Z"},"accession":"S-EPMC9700379","cross_references":{"pubmed":["36066342"],"doi":["10.1089/thy.2022.0327"]}}