{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(6)"],"submitter":["Yang XC"],"pubmed_abstract":["As a transcription factor of the Pit-Oct-Unc (POU) domain family, octamer-binding transcription factor 6 ( <i>OCT6</i>) participates in various aspects of stem cell development and differentiation. At present, however, its role in porcine-induced pluripotent stem cells (piPSCs) remains unclear. Here, we explored the function of <i>OCT6</i> in piPSCs. We found that piPSCs overexpressing <i>OCT6</i> maintained colony morphology and pluripotency under differentiation conditions, with a similar gene expression pattern to that of non-differentiated piPSCs. Functional analysis revealed that <i>OCT6</i> attenuated the adverse effects of extracellular signal-regulated kinase (ERK) signaling pathway inhibition on piPSC pluripotency by activating phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling activity. Our research sheds new light on the mechanism by which <i>OCT6</i> promotes PSC maintenance."],"journal":["Zoological research"],"pagination":["911-922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700490"],"repository":["biostudies-literature"],"pubmed_title":["<i>OCT6</i> inhibits differentiation of porcine-induced pluripotent stem cells through MAPK and PI3K signaling regulation."],"pmcid":["PMC9700490"],"pubmed_authors":["Yang XC","Shen QY","Hua JL","Peng S","Wu XL","Li WH","Wu XJ","Li YX"],"additional_accession":[]},"is_claimable":false,"name":"<i>OCT6</i> inhibits differentiation of porcine-induced pluripotent stem cells through MAPK and PI3K signaling regulation.","description":"As a transcription factor of the Pit-Oct-Unc (POU) domain family, octamer-binding transcription factor 6 ( <i>OCT6</i>) participates in various aspects of stem cell development and differentiation. At present, however, its role in porcine-induced pluripotent stem cells (piPSCs) remains unclear. Here, we explored the function of <i>OCT6</i> in piPSCs. We found that piPSCs overexpressing <i>OCT6</i> maintained colony morphology and pluripotency under differentiation conditions, with a similar gene expression pattern to that of non-differentiated piPSCs. Functional analysis revealed that <i>OCT6</i> attenuated the adverse effects of extracellular signal-regulated kinase (ERK) signaling pathway inhibition on piPSC pluripotency by activating phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling activity. Our research sheds new light on the mechanism by which <i>OCT6</i> promotes PSC maintenance.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T09:44:05.161Z","creation":"2025-04-06T13:06:58.862Z"},"accession":"S-EPMC9700490","cross_references":{"pubmed":["36052561"],"doi":["10.24272/j.issn.2095-8137.2022.220"]}}