{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kilpi F"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["473"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9700972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Whether women's physical function in mid-life is related to their reproductive age is not known. The objectives of this study were to examine and compare changes in physical function in women by reproductive age, measured as time since final menstrual period (FMP), and chronological age, and to explore associations with repeatedly assessed levels of reproductive hormones.<h4>Methods</h4>We used data from 2319 UK women with up to three repeated measurements of physical function (median length of follow up: 2 years), focusing on changes occurring in women experiencing a natural menopausal transition. The main outcome was a composite physical function score that incorporated assessments of strength (grip strength), balance (one-leg stand) and cardiorespiratory fitness (time"],"journal":["BMC women's health"],"pubmed_title":["Changes in women's physical function in mid-life by reproductive age and hormones: a longitudinal study."],"pmcid":["PMC9700972"],"funding_grant_id":["NF-SI-0616-10102","G9815508","217065/Z/19/Z","G1001357","202802/Z/16/Z","MC_PC_15018","MC_UU_00011/6","MC_PC_19009"],"pubmed_authors":["Soares AG","Nelson SM","Lawlor DA","Kilpi F","Welsh P","Sattar N","Fraser A","Clayton GL","Tilling K"],"additional_accession":[]},"is_claimable":false,"name":"Changes in women's physical function in mid-life by reproductive age and hormones: a longitudinal study.","description":"<h4>Background</h4>Whether women's physical function in mid-life is related to their reproductive age is not known. The objectives of this study were to examine and compare changes in physical function in women by reproductive age, measured as time since final menstrual period (FMP), and chronological age, and to explore associations with repeatedly assessed levels of reproductive hormones.<h4>Methods</h4>We used data from 2319 UK women with up to three repeated measurements of physical function (median length of follow up: 2 years), focusing on changes occurring in women experiencing a natural menopausal transition. The main outcome was a composite physical function score that incorporated assessments of strength (grip strength), balance (one-leg stand) and cardiorespiratory fitness (time","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T22:59:58.046Z","creation":"2025-04-19T22:59:58.046Z"},"accession":"S-EPMC9700972","cross_references":{"pubmed":["36434722"],"doi":["10.1186/s12905-022-02070-9"]}}