{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(3)"],"submitter":["Zhang RS"],"pubmed_abstract":["The relationship between folic acid and <i>S</i>-adenosylhomocysteine (SAH) is controversial. This study aims to explore the effect of different doses of folic acid supplementation on SAH levels in hypertensive patients and the modification of methylene-tetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A randomized, double-blind, controlled clinical trial was conducted. Hypertensive patients aged 45-75 years without a history of stroke and cardiovascular disease were selected, who were randomly assigned to one of 8 dose groups. This trial has been registered with Trial Number: ChiCTR1800016135. In the total population, folic acid supplementation of 0.4-2.0 mg/day had no effect on SAH level (β = 0.47, 95% CI: -0.86-1.79, <i>p</i> = 0.491), while folic acid supplementation of 2.4 m"],"journal":["Journal of clinical biochemistry and nutrition"],"pagination":["238-244"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9701592"],"repository":["biostudies-literature"],"pubmed_title":["Effect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial."],"pmcid":["PMC9701592"],"pubmed_authors":["Zhang RS","Tang L","Wang R","Zhang Y","Zhang X","Xu YP","Tang GF","Shu J","Zou JF","Chen H","Shi XL","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Effect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial.","description":"The relationship between folic acid and <i>S</i>-adenosylhomocysteine (SAH) is controversial. This study aims to explore the effect of different doses of folic acid supplementation on SAH levels in hypertensive patients and the modification of methylene-tetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A randomized, double-blind, controlled clinical trial was conducted. Hypertensive patients aged 45-75 years without a history of stroke and cardiovascular disease were selected, who were randomly assigned to one of 8 dose groups. This trial has been registered with Trial Number: ChiCTR1800016135. In the total population, folic acid supplementation of 0.4-2.0 mg/day had no effect on SAH level (β = 0.47, 95% CI: -0.86-1.79, <i>p</i> = 0.491), while folic acid supplementation of 2.4 m","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-21T14:27:56.2Z","creation":"2024-11-08T10:55:47.761Z"},"accession":"S-EPMC9701592","cross_references":{"pubmed":["36447492"],"doi":["10.3164/jcbn.22-13"]}}