biostudies-literatureUnknown71(3)Zhang RSThe relationship between folic acid and <i>S</i>-adenosylhomocysteine (SAH) is controversial. This study aims to explore the effect of different doses of folic acid supplementation on SAH levels in hypertensive patients and the modification of methylene-tetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A randomized, double-blind, controlled clinical trial was conducted. Hypertensive patients aged 45-75 years without a history of stroke and cardiovascular disease were selected, who were randomly assigned to one of 8 dose groups. This trial has been registered with Trial Number: ChiCTR1800016135. In the total population, folic acid supplementation of 0.4-2.0 mg/day had no effect on SAH level (β = 0.47, 95% CI: -0.86-1.79, <i>p</i> = 0.491), while folic acid supplementation of 2.4 mJournal of clinical biochemistry and nutrition238-244https://www.ebi.ac.uk/biostudies/studies/S-EPMC9701592biostudies-literatureEffect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial.PMC9701592Zhang RSTang LWang RZhang YZhang XXu YPTang GFShu JZou JFChen HShi XLWang LfalseEffect of folic acid supplementation on the change of plasma <i>S</i>-adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial.The relationship between folic acid and <i>S</i>-adenosylhomocysteine (SAH) is controversial. This study aims to explore the effect of different doses of folic acid supplementation on SAH levels in hypertensive patients and the modification of methylene-tetrahydrofolate reductase (MTHFR) C677T gene polymorphism. A randomized, double-blind, controlled clinical trial was conducted. Hypertensive patients aged 45-75 years without a history of stroke and cardiovascular disease were selected, who were randomly assigned to one of 8 dose groups. This trial has been registered with Trial Number: ChiCTR1800016135. In the total population, folic acid supplementation of 0.4-2.0 mg/day had no effect on SAH level (β = 0.47, 95% CI: -0.86-1.79, <i>p</i> = 0.491), while folic acid supplementation of 2.4 m2022-01-01T00:00:00Z2022 Nov2025-04-21T14:27:56.2Z2024-11-08T10:55:47.761ZS-EPMC97015923644749210.3164/jcbn.22-13