biostudies-literatureIanevski ANTNU Norwegian University of Science and TechnologyEesti Teadusfondi605https://www.ebi.ac.uk/biostudies/studies/S-EPMC9701656biostudies-literatureUnknown79(12)The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development. Here, we briefly reviewed 7 classes of antiviral agents: neutralizing antibodies, neutralizing recombinant soluble human receptors, antiviral CRISPR/Cas systems, interferons, antiviral peptides, antiviral nucleic acid polymers, and antiviral small molecules. Interferons and some small molecules alone or in combinations possess broad-spectrum antiviral activity, which could be beneficial for treatment of emerging and re-emerging viral infections.Cellular and molecular life sciences : CMLSSeven classes of antiviral agents.PMC9701656MOBTT49Anunnitipat KIanevski AAhmad SOksenych VZusinaite EBjoras MKainov DETenson TfalseSeven classes of antiviral agents.The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. About a hundred mono- and combination antiviral drugs have been already approved, whereas thousands are in development. Here, we briefly reviewed 7 classes of antiviral agents: neutralizing antibodies, neutralizing recombinant soluble human receptors, antiviral CRISPR/Cas systems, interferons, antiviral peptides, antiviral nucleic acid polymers, and antiviral small molecules. Interferons and some small molecules alone or in combinations possess broad-spectrum antiviral activity, which could be beneficial for treatment of emerging and re-emerging viral infections.2022-01-01T00:00:00Z2022 Nov2025-04-04T08:09:02.2Z2025-02-19T01:56:22.678ZS-EPMC97016563643610810.1007/s00018-022-04635-1