{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Shi H"],"pubmed_abstract":["Three new antibacterial spirooxindole alkaloids, spirobrefeldins A-C (1-3), together with four known analogs, spirotryprostatin M (4), spirotryprostatin G (5), 12β-hydroxyverruculogen TR-2 (6), and 12α-hydroxyverruculogen TR-2 (7), were isolated from terrestrial fungus <i>Penicillium brefeldianum.</i> All the new compounds were elucidated extensively by the interpretation of their NMR (1D and 2D) spectra and high-resolution mass data, and their absolute configurations were determined by computational chemistry and CD spectra. The absolute configurations of spiro carbon C-2 in spirotryprostatin G (5) and spirotryprostatin C in literature were reported as <i>S</i>, which were revised to <i>R</i> based on experimental and calculated CD spectra. All the compounds were evaluated for their antim"],"journal":["Frontiers in microbiology"],"pagination":["1046099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9702524"],"repository":["biostudies-literature"],"pubmed_title":["Antibacterial spirooxindole alkaloids from <i>Penicillium brefeldianum</i> inhibit dimorphism of pathogenic smut fungi."],"pmcid":["PMC9702524"],"pubmed_authors":["Jiang J","He F","Jie L","Zhang H","Jiang H","Su Z","Liu D","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Antibacterial spirooxindole alkaloids from <i>Penicillium brefeldianum</i> inhibit dimorphism of pathogenic smut fungi.","description":"Three new antibacterial spirooxindole alkaloids, spirobrefeldins A-C (1-3), together with four known analogs, spirotryprostatin M (4), spirotryprostatin G (5), 12β-hydroxyverruculogen TR-2 (6), and 12α-hydroxyverruculogen TR-2 (7), were isolated from terrestrial fungus <i>Penicillium brefeldianum.</i> All the new compounds were elucidated extensively by the interpretation of their NMR (1D and 2D) spectra and high-resolution mass data, and their absolute configurations were determined by computational chemistry and CD spectra. The absolute configurations of spiro carbon C-2 in spirotryprostatin G (5) and spirotryprostatin C in literature were reported as <i>S</i>, which were revised to <i>R</i> based on experimental and calculated CD spectra. All the compounds were evaluated for their antim","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T12:02:09.299Z","creation":"2025-02-19T03:00:06.176Z"},"accession":"S-EPMC9702524","cross_references":{"pubmed":["36452922"],"doi":["10.3389/fmicb.2022.1046099"]}}