biostudies-literatureUnknown10Sepulveda-Robles O<h4>Background</h4>The distribution of <i>RUNX1-RUNXT1</i>, <i>PML-RARA</i>, <i>CBFB-MYH11</i>, <i>BCR-ABL1^p210</i> , and <i>KMT2A-MLLT3</i> in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with <i>de novo</i> AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.<h4>Methods</h4>We retrospectively analyzed the presence of <i>RUNX1-RUNXT1</i>, <i>PML-RARA</i>, <i>CBFB-MYH11</i>, <i>BCR-ABL1^p210</i> , and <i>KMT2A-MLLT3</i> by RT-PCR among 77 patients (<18 years) diagnosed with <i>de novo</i>Frontiers in pediatrics946690https://www.ebi.ac.uk/biostudies/studies/S-EPMC9702800biostudies-literatureAnalytical study of <i>RUNX1-RUNXT1</i>, <i>PML-RARA</i>, <i>CBFB-MYH11</i>, <i>BCR-ABL1^p210</i> , and <i>KMT2-MLLT3</i> in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL).PMC9702800Flores-Villegas LVPerez-Saldivar MLRosas-Vargas HTorres-Nava JRMata-Rocha MBekker-Mendez VCMorales-Castillo BASantillan-Juarez JDMedina-Sanson ANajera-Cortes ASVelazquez-Avina MMNunez-Enriquez JCFlores-Lujano JBravata-Alcantara JCDominguez-Catzin VOrozco-Ruiz DDe Ita MGomez-Flores EJimenez-Hernandez ESepulveda-Robles OMerino-Pasaye LEMejia-Arangure JMAmador-Sanchez RSanchez-Escobar NPenaloza-Gonzalez JGSolis-Labastida KAJimenez-Morales SMartin-Trejo JAEspinosa-Elizondo RMRangel-Lopez AGonzalez-Avila AIfalseAnalytical study of <i>RUNX1-RUNXT1</i>, <i>PML-RARA</i>, <i>CBFB-MYH11</i>, <i>BCR-ABL1^p210</i> , and <i>KMT2-MLLT3</i> in Mexican children with acute myeloid leukemia: A multicenter study of the Mexican interinstitutional group for the identification of the causes of childhood leukemia (MIGICCL).<h4>Background</h4>The distribution of <i>RUNX1-RUNXT1</i>, <i>PML-RARA</i>, <i>CBFB-MYH11</i>, <i>BCR-ABL1^p210</i> , and <i>KMT2A-MLLT3</i> in the pediatric population with acute myeloid leukemia (AML) in many countries of Latin America is largely unknown. Therefore, we aimed to investigate the frequency of these fusion genes in children with <i>de novo</i> AML from Mexico City, which has one of the highest incidence rates of acute leukemia in the world. Additionally, we explored their impact in mortality during the first year of treatment.<h4>Methods</h4>We retrospectively analyzed the presence of <i>RUNX1-RUNXT1</i>, <i>PML-RARA</i>, <i>CBFB-MYH11</i>, <i>BCR-ABL1^p210</i> , and <i>KMT2A-MLLT3</i> by RT-PCR among 77 patients (<18 years) diagnosed with <i>de novo</i>2022-01-01T00:00:00Z20222026-05-03T22:44:22.35Z2025-04-21T14:27:56.196ZS-EPMC97028003645234910.3389/fped.2022.946690