{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Messing M"],"pubmed_abstract":["The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack the ability to identify prospectively those patients who may require extended management. In this study of 90 ICU COVID-19 patients, we evaluated serum levels of four cytokines (IL-1β, IL-6, IL-10 and TNFα) as well as standard clinical and laboratory measurements. On 42 of these patients (binned into Initial and Replication Cohorts), we further performed CyTOF-based deep immunophenotyping of peripheral blood mononuclear cells with a panel of 38 antibodies. All measurements and patient samples were taken at time of ICU admission and retrospectively linked to patient clinical outcomes through statistical approaches. These analyses resulted in the definition of a new measure of patient clinical o"],"journal":["Frontiers in immunology"],"pagination":["1010216"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9703061"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes."],"pmcid":["PMC9703061"],"pubmed_authors":["Wellington CL","Cooper J","Shin SB","Messing M","Hughes MR","Ahmed N","Sekhon MS","Stukas S","Hamer MS","Li Y","Sin DD","McNagny KM","Leslie KB","Tung LW","Hoiland RL"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic peripheral blood biomarkers at ICU admission predict COVID-19 clinical outcomes.","description":"The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack the ability to identify prospectively those patients who may require extended management. In this study of 90 ICU COVID-19 patients, we evaluated serum levels of four cytokines (IL-1β, IL-6, IL-10 and TNFα) as well as standard clinical and laboratory measurements. On 42 of these patients (binned into Initial and Replication Cohorts), we further performed CyTOF-based deep immunophenotyping of peripheral blood mononuclear cells with a panel of 38 antibodies. All measurements and patient samples were taken at time of ICU admission and retrospectively linked to patient clinical outcomes through statistical approaches. These analyses resulted in the definition of a new measure of patient clinical o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T14:28:38.877Z","creation":"2025-04-21T14:28:38.877Z"},"accession":"S-EPMC9703061","cross_references":{"pubmed":["36451808"],"doi":["10.3389/fimmu.2022.1010216"]}}