biostudies-literatureGarg PMNIGMS NIH HHS10093-10102https://www.ebi.ac.uk/biostudies/studies/S-EPMC9704046biostudies-literatureUnknown35(25)<h4>Objective</h4>To investigate gestational age (GA) specific hematological and transfusion response patterns in preterm infants following necrotizing enterocolitis (NEC).<h4>Design</h4>A retrospective study comparing hematological/transfusion information in three GA groups' infants: Group A ≤ 28 weeks. Group B 28-32 weeks, Group C > 32 weeks following necrotizing enterocolitis.<h4>Results</h4>Group A infants responded with significantly higher WBC count, thrombocytopenia, higher absolute neutrophil, and higher absolute monocyte and lower absolute lymphocyte counts following NEC onset, received more blood transfusions before NEC onset (59.8 versus 30.0%; <i>p</i> = .007), and had higher odds of surgical NEC (OR 3.39 [95% CI 1.19-10.38]; <i>p</i> = .02) than group C. One unit increase in absolute lymphocyte count on the day, and 24 h following NEC was significantly associated with lower surgical NEC odds than groups C.<h4>Conclusion</h4>The infant's in-group A had significantly different hematological response patterns following NEC than infants with higher gestational age (groups B and C).The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal ObstetriciansGestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.PMC9704046U54 GM115428Paschal JLWare JAnsari MAYGarg PMO'Connor AHobart HLfalseGestational age-specific hematological patterns in preterm infants following necrotizing enterocolitis.<h4>Objective</h4>To investigate gestational age (GA) specific hematological and transfusion response patterns in preterm infants following necrotizing enterocolitis (NEC).<h4>Design</h4>A retrospective study comparing hematological/transfusion information in three GA groups' infants: Group A ≤ 28 weeks. Group B 28-32 weeks, Group C > 32 weeks following necrotizing enterocolitis.<h4>Results</h4>Group A infants responded with significantly higher WBC count, thrombocytopenia, higher absolute neutrophil, and higher absolute monocyte and lower absolute lymphocyte counts following NEC onset, received more blood transfusions before NEC onset (59.8 versus 30.0%; <i>p</i> = .007), and had higher odds of surgical NEC (OR 3.39 [95% CI 1.19-10.38]; <i>p</i> = .02) than group C. One unit increase in absolute lymphocyte count on the day, and 24 h following NEC was significantly associated with lower surgical NEC odds than groups C.<h4>Conclusion</h4>The infant's in-group A had significantly different hematological response patterns following NEC than infants with higher gestational age (groups B and C).2022-01-01T00:00:00Z2022 Dec2026-03-17T16:10:13.691Z2025-04-06T00:48:51.247ZS-EPMC97040463606273710.1080/14767058.2022.2115885