biostudies-literatureUnknown60(1)Henrotin YTilman SA<h4>Context</h4>Osteoarthritis (OA) of the hand is a common painful musculoskeletal disorder with no cure. There is a need for an efficient and safe treatment to relieve OA pain.<h4>Objective</h4>To investigate the effects of a <i>Curcuma longa</i> and <i>Boswellia serrata</i> food supplement in addition to standard care on hand pain.<h4>Materials and methods</h4>This open-label, non-controlled, post-observational study was based on 232 patients suffering from hand pain with or without joint deformity. Patients received a medical prescription for a three-month treatment with a food supplement containing 89 mg of <i>C. longa</i> dry extract, 120 mg of <i>B. serrata</i> resin, and 1.8 µg vitamin D. Pain was evaluated on a 10-point visual analog scale (VAS). The number of painful hand joints, patient satisfaction, nonsteroidal anti-inflammatory drugs intake, and side effects were also recorded.<h4>Results</h4>Baseline pain intensity (regression coefficient ± <i>SE</i>: -0.19 ± 0.01, <i>p</i> < 0.0001) and the number of painful joints (regression coefficient ± <i>SE</i>: -0.022 ± 0.0029, <i>p</i> < 0.0001) decreased significantly throughout the 3 months treatment period. NSAIDs intake and topical drug application were significantly decreased by 64% (<i>p</i> < 0.0001) and 79% (<i>p</i> < 0.0001) after 12 weeks, respectively. Only 3/239 (1.3%) patients reported side effects probably related to the product. 80.3% were satisfied with the treatment and 75.5% wished to continue treatment.<h4>Conclusion</h4>This is the first clinical trial showing that <i>C. longa</i> and <i>B. serrata</i> resin can relieve symptoms in patients with hand osteoarthritis. The study provides useful information for the design of a clinical trial including a broader population.Pharmaceutical biology2295-2299https://www.ebi.ac.uk/biostudies/studies/S-EPMC9704064biostudies-literature<i>Curcuma longa</i> and <i>Boswellia serrata</i> extract combination for hand osteoarthritis: an open-label pre-post trial.PMC9704064Delisse GDierckxsens YHenrotin YMaes NAlbert Afalse<i>Curcuma longa</i> and <i>Boswellia serrata</i> extract combination for hand osteoarthritis: an open-label pre-post trial.<h4>Context</h4>Osteoarthritis (OA) of the hand is a common painful musculoskeletal disorder with no cure. There is a need for an efficient and safe treatment to relieve OA pain.<h4>Objective</h4>To investigate the effects of a <i>Curcuma longa</i> and <i>Boswellia serrata</i> food supplement in addition to standard care on hand pain.<h4>Materials and methods</h4>This open-label, non-controlled, post-observational study was based on 232 patients suffering from hand pain with or without joint deformity. Patients received a medical prescription for a three-month treatment with a food supplement containing 89 mg of <i>C. longa</i> dry extract, 120 mg of <i>B. serrata</i> resin, and 1.8 µg vitamin D. Pain was evaluated on a 10-point visual analog scale (VAS). The number of painful hand joints, patient satisfaction, nonsteroidal anti-inflammatory drugs intake, and side effects were also recorded.<h4>Results</h4>Baseline pain intensity (regression coefficient ± <i>SE</i>: -0.19 ± 0.01, <i>p</i> < 0.0001) and the number of painful joints (regression coefficient ± <i>SE</i>: -0.022 ± 0.0029, <i>p</i> < 0.0001) decreased significantly throughout the 3 months treatment period. NSAIDs intake and topical drug application were significantly decreased by 64% (<i>p</i> < 0.0001) and 79% (<i>p</i> < 0.0001) after 12 weeks, respectively. Only 3/239 (1.3%) patients reported side effects probably related to the product. 80.3% were satisfied with the treatment and 75.5% wished to continue treatment.<h4>Conclusion</h4>This is the first clinical trial showing that <i>C. longa</i> and <i>B. serrata</i> resin can relieve symptoms in patients with hand osteoarthritis. The study provides useful information for the design of a clinical trial including a broader population.2022-01-01T00:00:00Z2022 Dec2025-04-19T22:47:43.43Z2025-04-19T22:47:43.43ZS-EPMC97040643641605910.1080/13880209.2022.2147550