{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Xia X"],"pubmed_abstract":["<h4>Objective</h4>Diarrhea-predominant irritable bowel syndrome (IBS-D) is a recurrent and common disease featuring dysbiotic intestinal microbiota, with limited treatments. Si-Jun-Zi Decoction (SJZD), a classic Chinese prescription, has been extensively used for IBS-D. This work aimed to explore the <i>ex vivo</i> interactions of SJZD and IBS-D's intestinal microbiota.<h4>Methods</h4>Five samples of intestinal microbiota collected from IBS-D volunteers and five age-matched healthy controls were recruited from the Affiliated Hospital, Chengdu University of Traditional Chinese Medicine (TCM). A representative mixture of intestinal microbiota was composed of an equal proportion of these fecal samples. To simulate the clinical interaction, this microbiota was cocultivated with SJZD at clinica"],"journal":["Frontiers in endocrinology"],"pagination":["1053103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9704418"],"repository":["biostudies-literature"],"pubmed_title":["Cocultivation of Chinese prescription and intestine microbiota: SJZD alleviated the major symptoms of IBS-D subjects by tuning neurotransmitter metabolism."],"pmcid":["PMC9704418"],"pubmed_authors":["Xia X","Ding W","Chen Q","Xie Y","Ding D","Wang X","Wang Y","Wang Z","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Cocultivation of Chinese prescription and intestine microbiota: SJZD alleviated the major symptoms of IBS-D subjects by tuning neurotransmitter metabolism.","description":"<h4>Objective</h4>Diarrhea-predominant irritable bowel syndrome (IBS-D) is a recurrent and common disease featuring dysbiotic intestinal microbiota, with limited treatments. Si-Jun-Zi Decoction (SJZD), a classic Chinese prescription, has been extensively used for IBS-D. This work aimed to explore the <i>ex vivo</i> interactions of SJZD and IBS-D's intestinal microbiota.<h4>Methods</h4>Five samples of intestinal microbiota collected from IBS-D volunteers and five age-matched healthy controls were recruited from the Affiliated Hospital, Chengdu University of Traditional Chinese Medicine (TCM). A representative mixture of intestinal microbiota was composed of an equal proportion of these fecal samples. To simulate the clinical interaction, this microbiota was cocultivated with SJZD at clinica","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-29T18:57:23.155Z","creation":"2024-11-21T01:22:36.986Z"},"accession":"S-EPMC9704418","cross_references":{"pubmed":["36452327"],"doi":["10.3389/fendo.2022.1053103"]}}