{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(12)"],"submitter":["Yao CY"],"pubmed_abstract":["Asian patientswith chronic lymphocytic leukemia (CLL) exhibit immunoglobulin heavy variable (IGHV) gene repertoires that are distinct from those observed in Western populations, and a higher proportion of Asian CLL patients carry heavy loads of somatic hypermutations (SHM) within the B-cell receptor immunoglobulins (BcR IG). Due to the low regional incidence of CLL in Asia, only a limited number of studies had attempted to probe the phenomenon of BcR IG stereotypy in Asian populations. In this study, we analyzed the IGHV-IGHD-IGHJ gene rearrangements from a series of 255 CLL patients recruited in a nationwide, multicenter study in Taiwan. Our analysis revealed that the IGHV gene repertoire was characterized by evident biases, with IGHV3-7, IGHV4-34, and IGHV3-23 being the most frequent rea"],"journal":["HemaSphere"],"pagination":["e803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9704955"],"repository":["biostudies-literature"],"pubmed_title":["Distinct Immunogenetic Profiles of Chronic Lymphocytic Leukemia in Asia: A Taiwan Cooperative Oncology Group Registry Study."],"pmcid":["PMC9704955"],"pubmed_authors":["Tsou HH","Agathangelidis A","Yao CY","Lin LI","Wu SJ","Yao M","Chuang SS","Chou WC","Chen TY","Chao TY","Feng WL","Yu YB","Hwang WL","Liu TC","Tien HF","Lin J","Ghia P","Wang CC","Yeh SP","Gau JP"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Immunogenetic Profiles of Chronic Lymphocytic Leukemia in Asia: A Taiwan Cooperative Oncology Group Registry Study.","description":"Asian patientswith chronic lymphocytic leukemia (CLL) exhibit immunoglobulin heavy variable (IGHV) gene repertoires that are distinct from those observed in Western populations, and a higher proportion of Asian CLL patients carry heavy loads of somatic hypermutations (SHM) within the B-cell receptor immunoglobulins (BcR IG). Due to the low regional incidence of CLL in Asia, only a limited number of studies had attempted to probe the phenomenon of BcR IG stereotypy in Asian populations. In this study, we analyzed the IGHV-IGHD-IGHJ gene rearrangements from a series of 255 CLL patients recruited in a nationwide, multicenter study in Taiwan. Our analysis revealed that the IGHV gene repertoire was characterized by evident biases, with IGHV3-7, IGHV4-34, and IGHV3-23 being the most frequent rea","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T11:49:31.905Z","creation":"2025-04-05T11:49:31.905Z"},"accession":"S-EPMC9704955","cross_references":{"pubmed":["36452029"],"doi":["10.1097/HS9.0000000000000803"]}}