biostudies-literatureUnknown37(46)Kim HISeoul Clinical Laboratories Healthcare Co., Ltd<h4>Background</h4>Single nucleotide polymorphisms (SNPs) are reportedly associated with repeated abortion. Thus, genetic analysis based on race is the key to developing accurate diagnostic tests. This study analyzed the genetic polymorphisms of recurrent pregnancy loss (RPL) patients among Korean women compared to the controls.<h4>Methods</h4>In 53 women of RPL group and 50 controls, the genetic analysis was performed. The genotype distribution and allele frequency were analyzed statistically for the difference between the two groups. The association between each SNP marker and RPL risk was analyzed.<h4>Results</h4>The genotypes of LEPR, endothelial nitric oxide synthase (eNOS), KDR, miR-27a, miR-449b, and tumor necrosis factor-alpha (TNF-α) were analyzed using odds ratio (OR) with 95% coJournal of Korean medical sciencee336https://www.ebi.ac.uk/biostudies/studies/S-EPMC9705206biostudies-literatureIdentification of Single Nucleotide Polymorphisms as Biomarkers for Recurrent Pregnancy Loss in Korean Women.PMC9705206Lee SPark JKim HILee BSPark SLee KRYun BHChoi EAHwang YIPaik ECCho SChoi YSLee JHSeo SKfalseIdentification of Single Nucleotide Polymorphisms as Biomarkers for Recurrent Pregnancy Loss in Korean Women.<h4>Background</h4>Single nucleotide polymorphisms (SNPs) are reportedly associated with repeated abortion. Thus, genetic analysis based on race is the key to developing accurate diagnostic tests. This study analyzed the genetic polymorphisms of recurrent pregnancy loss (RPL) patients among Korean women compared to the controls.<h4>Methods</h4>In 53 women of RPL group and 50 controls, the genetic analysis was performed. The genotype distribution and allele frequency were analyzed statistically for the difference between the two groups. The association between each SNP marker and RPL risk was analyzed.<h4>Results</h4>The genotypes of LEPR, endothelial nitric oxide synthase (eNOS), KDR, miR-27a, miR-449b, and tumor necrosis factor-alpha (TNF-α) were analyzed using odds ratio (OR) with 95% co2022-01-01T00:00:00Z2022 Nov2025-04-19T15:38:27.24Z2025-04-19T15:38:27.24ZS-EPMC97052063663102810.3346/jkms.2022.37.e336