{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Sun Y"],"pubmed_abstract":["Psoriasis is more common in patients with inflammatory bowel disease (IBD) than in the general population. Similarly, patients with psoriasis or psoriatic arthritis (PsA) have a higher incidence of IBD. However, whether this association is causal remains unknown. Therefore, we used a two-sample bidirectional Mendelian randomization (MR) analysis to identify this relationship. According to MR analysis, psoriasis and PsA causally increased the odds of developing Crohn's disease (OR = 1.350 (1.066-1.709) P = 0.013; OR = 1.319 (1.166-1.492) P < 0.001). In contrast, MR estimates gave little support to a possible causal effect of psoriasis, PsA, on ulcerative colitis (OR = 1.101 (0.905-1.340) P = 0.335; OR = 1.007 (0.941-1.078) P = 0.831). Similarly, the reverse analysis suggested the Crohn's di"],"journal":["Scientific reports"],"pagination":["20526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9705442"],"repository":["biostudies-literature"],"pubmed_title":["The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases."],"pmcid":["PMC9705442"],"pubmed_authors":["Li Y","Zhang J","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases.","description":"Psoriasis is more common in patients with inflammatory bowel disease (IBD) than in the general population. Similarly, patients with psoriasis or psoriatic arthritis (PsA) have a higher incidence of IBD. However, whether this association is causal remains unknown. Therefore, we used a two-sample bidirectional Mendelian randomization (MR) analysis to identify this relationship. According to MR analysis, psoriasis and PsA causally increased the odds of developing Crohn's disease (OR = 1.350 (1.066-1.709) P = 0.013; OR = 1.319 (1.166-1.492) P < 0.001). In contrast, MR estimates gave little support to a possible causal effect of psoriasis, PsA, on ulcerative colitis (OR = 1.101 (0.905-1.340) P = 0.335; OR = 1.007 (0.941-1.078) P = 0.831). Similarly, the reverse analysis suggested the Crohn's di","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T09:40:44.178Z","creation":"2025-04-06T13:08:50.174Z"},"accession":"S-EPMC9705442","cross_references":{"pubmed":["36443384"],"doi":["10.1038/s41598-022-24872-5"]}}