{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Son SH"],"funding":["National Research Foundation of Korea"],"pagination":["676-685"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9706018"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(5)"],"pubmed_abstract":["RNA-binding proteins are involved in RNA metabolism and posttranscriptional regulation of various fundamental biological processes. The PUF family of RNA-binding proteins is highly conserved in eukaryotes, and its members regulate gene expression, mitochondrial biogenesis, and RNA processing. However, their biological functions in <i>Aspergillus</i> species remain mostly unknown in filamentous fungi. Here we have characterized the puf genes in the model organism <i>Aspergillus nidulans</i>. We generated deletion mutant strains for the five putative puf genes present in the <i>A. nidulans</i> genome and investigated their developmental phenotypes. Deletion of <i>pufA</i> or <i>pufE</i> affected fungal growth and asexual development. <i>pufA</i> mutants exhibited decreased production of asex"],"journal":["Journal of microbiology and biotechnology"],"pubmed_title":["Functions of PUF Family RNA-Binding Proteins in <i>Aspergillus nidulans</i>."],"pmcid":["PMC9706018"],"funding_grant_id":["NRF-2020R1C1C1004473"],"pubmed_authors":["Park HS","Son SH","Jang SY"],"additional_accession":[]},"is_claimable":false,"name":"Functions of PUF Family RNA-Binding Proteins in <i>Aspergillus nidulans</i>.","description":"RNA-binding proteins are involved in RNA metabolism and posttranscriptional regulation of various fundamental biological processes. The PUF family of RNA-binding proteins is highly conserved in eukaryotes, and its members regulate gene expression, mitochondrial biogenesis, and RNA processing. However, their biological functions in <i>Aspergillus</i> species remain mostly unknown in filamentous fungi. Here we have characterized the puf genes in the model organism <i>Aspergillus nidulans</i>. We generated deletion mutant strains for the five putative puf genes present in the <i>A. nidulans</i> genome and investigated their developmental phenotypes. Deletion of <i>pufA</i> or <i>pufE</i> affected fungal growth and asexual development. <i>pufA</i> mutants exhibited decreased production of asex","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-29T11:06:38.92Z","creation":"2025-04-06T19:47:48.129Z"},"accession":"S-EPMC9706018","cross_references":{"pubmed":["33746193"],"doi":["10.4014/jmb.2101.01011"]}}