biostudies-literatureUnknown10Liu S<h4>Objective</h4>Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection combined with human coronavirus-229E (HCoV-229E) is very rare.<h4>Study design and setting</h4>Clinical manifestations, laboratory examinations, and disease severity were compared between three groups: one coinfected with HAdV-Ad7 and HCoV-229E, one infected only with adenovirus (mono-adenovirus), and one infected only with HCoV-229E (mono-HCoV-229E).<h4>Results</h4>From July to August 2019, there were 24 hospitalized children: two were coinfected with HAdV-Ad7 and HCoV-229E, and 21 were infected with a single adenovirus infection. Finally, one 14-year-old boy presented with a high fever, but tested negative for HAdV-Ad7 and HCoV-229E. Additionally, three adult asymptotic cases with HCoV-229E were screened. No significant difference in age was found in the coinfection and mono-adenovirus groups (11 vs. 8 years, <i>p</i> = 0.332). Both groups had the same incubation period (2.5 vs. 3 days, <i>p</i> = 0.8302), fever duration (2.5 vs. 2.9 days, <i>p</i> = 0.5062), and length of hospital stay (7 vs. 6.76 days, <i>p</i> = 0.640). No obvious differences were found in viral loads between the coinfection and mono-adenovirus groups (25.4 vs. 23.7, <i>p</i> = 0.570), or in the coinfection and mono-HCoV-229E groups (32.9 vs. 30.06, <i>p</i> = 0.067). All cases recovered and were discharged from the hospital.<h4>Conclusion</h4>HAdV-Ad7 and HCoV-229E coinfection in healthy children may not increase the clinical severity or prolong the clinical course. The specific interaction mechanism between the viruses requires further study.Frontiers in public health1048108https://www.ebi.ac.uk/biostudies/studies/S-EPMC9706225biostudies-literatureThe clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus.PMC9706225Cai JZhu HLiu SSun WZhu AChen EYing LWu HWang LQin SPan JLou HChen YYu ZfalseThe clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus.<h4>Objective</h4>Human adenovirus (HAdV) coinfection with other respiratory viruses is common, but adenovirus infection combined with human coronavirus-229E (HCoV-229E) is very rare.<h4>Study design and setting</h4>Clinical manifestations, laboratory examinations, and disease severity were compared between three groups: one coinfected with HAdV-Ad7 and HCoV-229E, one infected only with adenovirus (mono-adenovirus), and one infected only with HCoV-229E (mono-HCoV-229E).<h4>Results</h4>From July to August 2019, there were 24 hospitalized children: two were coinfected with HAdV-Ad7 and HCoV-229E, and 21 were infected with a single adenovirus infection. Finally, one 14-year-old boy presented with a high fever, but tested negative for HAdV-Ad7 and HCoV-229E. Additionally, three adult asymptotic cases with HCoV-229E were screened. No significant difference in age was found in the coinfection and mono-adenovirus groups (11 vs. 8 years, <i>p</i> = 0.332). Both groups had the same incubation period (2.5 vs. 3 days, <i>p</i> = 0.8302), fever duration (2.5 vs. 2.9 days, <i>p</i> = 0.5062), and length of hospital stay (7 vs. 6.76 days, <i>p</i> = 0.640). No obvious differences were found in viral loads between the coinfection and mono-adenovirus groups (25.4 vs. 23.7, <i>p</i> = 0.570), or in the coinfection and mono-HCoV-229E groups (32.9 vs. 30.06, <i>p</i> = 0.067). All cases recovered and were discharged from the hospital.<h4>Conclusion</h4>HAdV-Ad7 and HCoV-229E coinfection in healthy children may not increase the clinical severity or prolong the clinical course. The specific interaction mechanism between the viruses requires further study.2022-01-01T00:00:00Z20222025-04-03T21:30:35.743Z2025-04-03T21:30:35.743ZS-EPMC97062253645733110.3389/fpubh.2022.1048108