{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Richter L"],"funding":["H2020 Excellent Science","Bundesbehörden der Schweizerischen Eidgenossenschaft"],"pagination":["18990-19001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9706661"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a dangerous and widespread risk, to date, there are no effective methods to avoid them. Here we present a peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables irreversible deactivation of the wide range of T-like phages (including the"],"journal":["ACS nano"],"pubmed_title":["Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections."],"pmcid":["PMC9706661"],"funding_grant_id":["754462"],"pubmed_authors":["Stevens CA","Julia LR","Malinverni C","Stellacci F","Richter L","Wei L","Los M","Silva PJ"],"additional_accession":[]},"is_claimable":false,"name":"Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections.","description":"One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a dangerous and widespread risk, to date, there are no effective methods to avoid them. Here we present a peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables irreversible deactivation of the wide range of T-like phages (including the","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-05T09:43:27.834Z","creation":"2025-04-05T09:43:27.834Z"},"accession":"S-EPMC9706661","cross_references":{"pubmed":["36259638"],"doi":["10.1021/acsnano.2c07896"]}}