biostudies-literatureRichter LH2020 Excellent ScienceBundesbehörden der Schweizerischen Eidgenossenschaft18990-19001https://www.ebi.ac.uk/biostudies/studies/S-EPMC9706661biostudies-literatureUnknown16(11)One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a dangerous and widespread risk, to date, there are no effective methods to avoid them. Here we present a peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables irreversible deactivation of the wide range of T-like phages (including theACS nanoPeptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections.PMC9706661754462Stevens CAJulia LRMalinverni CStellacci FRichter LWei LLos MSilva PJfalsePeptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections.One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a dangerous and widespread risk, to date, there are no effective methods to avoid them. Here we present a peptide-grafted compounds that irreversibly deactivate bacteriophages and remain safe for bacteria and mammalian cells. The active compounds consist of a core (cyclodextrin or gold nanoparticle) coated with a hydrophobic chain terminated with a peptide selective for bacteriophages. Such peptides were selected via a phage display technique. This approach enables irreversible deactivation of the wide range of T-like phages (including the2022-01-01T00:00:00Z2022 Nov2025-04-05T09:43:27.834Z2025-04-05T09:43:27.834ZS-EPMC97066613625963810.1021/acsnano.2c07896