biostudies-literatureRamaraju HNHLBI NIH HHSNational Institute of Health, Heart Lung and Blood InstituteGeorgia Institute of Technology103965https://www.ebi.ac.uk/biostudies/studies/S-EPMC9707619biostudies-literatureUnknown110Structural repair of soft tissue for regenerative therapies can be advanced by developing biocompatible and bioresorbable materials with mechanical properties similar to the tissue targeted for therapy. Developing new materials modeling soft tissue mechanics can mitigate many limitations of material based therapies, specifically concerning the mechanical stress and deformation the material imposes on surrounding tissue structures. However, many elastomeric materials used in soft tissue repair lack the ability to be delivered through minimally invasive surgical (MIS) or transcatheter routes and require open surgical approaches for placement and application. We have developed a biocompatible and fully biodegradable shape memory elastomer, poly-(glycerol dodecanedioate) (PGD), which fulfills Journal of the mechanical behavior of biomedical materialsModulating nonlinear elastic behavior of biodegradable shape memory elastomer and small intestinal submucosa(SIS) composites for soft tissue repair.PMC9707619R21 HL126004NIH R21 HL126004Ramaraju HBocks MLUl-Haque AVerga ASHollister SJfalseModulating nonlinear elastic behavior of biodegradable shape memory elastomer and small intestinal submucosa(SIS) composites for soft tissue repair.Structural repair of soft tissue for regenerative therapies can be advanced by developing biocompatible and bioresorbable materials with mechanical properties similar to the tissue targeted for therapy. Developing new materials modeling soft tissue mechanics can mitigate many limitations of material based therapies, specifically concerning the mechanical stress and deformation the material imposes on surrounding tissue structures. However, many elastomeric materials used in soft tissue repair lack the ability to be delivered through minimally invasive surgical (MIS) or transcatheter routes and require open surgical approaches for placement and application. We have developed a biocompatible and fully biodegradable shape memory elastomer, poly-(glycerol dodecanedioate) (PGD), which fulfills 2020-01-01T00:00:00Z2020 Oct2025-04-04T19:37:52.282Z2025-04-04T19:37:52.282ZS-EPMC97076193295725610.1016/j.jmbbm.2020.103965