{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jorge-Smeding E"],"funding":["Ambassade de France en Uruguay, Campus France","Agencia Nacional de Investigación e Innovacion","APISGENE"],"pagination":["e0277458"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9707789"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(11)"],"pubmed_abstract":["This study explored plasma biomarkers and metabolic pathways underlying feed efficiency measured as residual feed intake (RFI) in Charolais heifers. A total of 48 RFI extreme individuals (High-RFI, n = 24; Low-RFI, n = 24) were selected from a population of 142 heifers for classical plasma metabolite and hormone quantification and plasma metabolomic profiling through untargeted LC-MS. Most efficient heifers (Low-RFI) had greater (P = 0.03) plasma concentrations of IGF-1 and tended to have (P = 0.06) a lower back fat depth compared to least efficient heifers. However, no changes were noted (P ≥ 0.10) for plasma concentrations of glucose, insulin, non-esterified fatty acids, β-hydroxybutyrate and urea. The plasma metabolomic dataset comprised 3,457 ions with none significantly differing between RFI classes after false discovery rate correction (FDR > 0.10). Among the 101 ions having a raw P < 0.05 for the RFI effect, 13 were putatively annotated by using internal databases and 6 compounds were further confirmed with standards. Metabolic pathway analysis from these 6 confirmed compounds revealed that the branched chain amino acid metabolism was significantly (FDR < 0.05) impacted by the RFI classes. Our results confirmed for the first time in beef heifers previous findings obtained in male beef cattle and pointing to changes in branched-chain amino acids metabolism along with that of body composition as biological mechanisms related to RFI. Further studies are warranted to ascertain whether there is a cause-and-effect relationship between these mechanisms and RFI."],"journal":["PloS one"],"pubmed_title":["Untargeted metabolomics confirms the association between plasma branched chain amino acids and residual feed intake in beef heifers."],"pmcid":["PMC9707789"],"funding_grant_id":["928831G","POS_NAC_2017_1_141119"],"pubmed_authors":["Centeno D","Taussat S","Durand S","Cantalapiedra-Hijar G","Polakof S","Petera M","Bonnet M","Jorge-Smeding E"],"additional_accession":[]},"is_claimable":false,"name":"Untargeted metabolomics confirms the association between plasma branched chain amino acids and residual feed intake in beef heifers.","description":"This study explored plasma biomarkers and metabolic pathways underlying feed efficiency measured as residual feed intake (RFI) in Charolais heifers. A total of 48 RFI extreme individuals (High-RFI, n = 24; Low-RFI, n = 24) were selected from a population of 142 heifers for classical plasma metabolite and hormone quantification and plasma metabolomic profiling through untargeted LC-MS. Most efficient heifers (Low-RFI) had greater (P = 0.03) plasma concentrations of IGF-1 and tended to have (P = 0.06) a lower back fat depth compared to least efficient heifers. However, no changes were noted (P ≥ 0.10) for plasma concentrations of glucose, insulin, non-esterified fatty acids, β-hydroxybutyrate and urea. The plasma metabolomic dataset comprised 3,457 ions with none significantly differing between RFI classes after false discovery rate correction (FDR > 0.10). Among the 101 ions having a raw P < 0.05 for the RFI effect, 13 were putatively annotated by using internal databases and 6 compounds were further confirmed with standards. Metabolic pathway analysis from these 6 confirmed compounds revealed that the branched chain amino acid metabolism was significantly (FDR < 0.05) impacted by the RFI classes. Our results confirmed for the first time in beef heifers previous findings obtained in male beef cattle and pointing to changes in branched-chain amino acids metabolism along with that of body composition as biological mechanisms related to RFI. Further studies are warranted to ascertain whether there is a cause-and-effect relationship between these mechanisms and RFI.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-29T11:07:28.19Z","creation":"2025-04-06T19:48:12.971Z"},"accession":"S-EPMC9707789","cross_references":{"pubmed":["36445891"],"doi":["10.1371/journal.pone.0277458"]}}