{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang WC"],"funding":["Howard Hughes Medical Institute"],"pagination":["1693-1705"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9708565"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(12)"],"pubmed_abstract":["Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and evaluation of trajectories for learning. Do hippocampal representations differentially contribute to experience-dependent learning of trajectories across spatial and relational contexts? In this study, we trained mice to navigate to a hidden target in a physical arena or manipulate a joystick to a virtual target to collect delayed rewards. In a navigational context, calcium imaging in freely moving mice revealed that synchronous CA1 reactivation was retrospective and important for evaluation of prior navigational trajectories. In a non-navigational context, reactivation was prospective and important for initiation of joystick trajectories, even in the same animals trained in both contexts. Adaptation of trajectories to a new target was well-explained by a common learning algorithm in which hippocampal activity makes dissociable contributions to reinforcement learning computations depending upon spatial context."],"journal":["Nature neuroscience"],"pubmed_title":["Hippocampal representations of foraging trajectories depend upon spatial context."],"pmcid":["PMC9708565"],"funding_grant_id":["N/A"],"pubmed_authors":["Jiang WC","Xu S","Dudman JT"],"additional_accession":[]},"is_claimable":false,"name":"Hippocampal representations of foraging trajectories depend upon spatial context.","description":"Animals learn trajectories to rewards in both spatial, navigational contexts and relational, non-navigational contexts. Synchronous reactivation of hippocampal activity is thought to be critical for recall and evaluation of trajectories for learning. Do hippocampal representations differentially contribute to experience-dependent learning of trajectories across spatial and relational contexts? In this study, we trained mice to navigate to a hidden target in a physical arena or manipulate a joystick to a virtual target to collect delayed rewards. In a navigational context, calcium imaging in freely moving mice revealed that synchronous CA1 reactivation was retrospective and important for evaluation of prior navigational trajectories. In a non-navigational context, reactivation was prospective and important for initiation of joystick trajectories, even in the same animals trained in both contexts. Adaptation of trajectories to a new target was well-explained by a common learning algorithm in which hippocampal activity makes dissociable contributions to reinforcement learning computations depending upon spatial context.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-03T22:42:45.94Z","creation":"2025-04-05T09:43:46.89Z"},"accession":"S-EPMC9708565","cross_references":{"pubmed":["36446934"],"doi":["10.1038/s41593-022-01201-7"]}}