biostudies-literatureUnknown13Tang CYangyinqingfei Decoction (YYQFD), a traditional Chinese prescription, is well known in the treatment of diphtheria and lung-related diseases in clinic. However, whether it can be used to block the lung injury caused by air pollutant remains unclear. In the present study, the effect of YYQFD was addressed using a PM_2.5-induced lung injury mice model. It was shown that YYQFD significantly improved pulmonary functions of mice exposed to PM_2.5, the levels of IL-6, TNF-α and MDA were decreased while SOD levels were increased in serum and bronchoalveolar fluid. The potential mechanism of YYQFD was then delved using metabolomic and proteomic techniques. The protein-metabolite joint analysis showed that YYQFD regulated the biosynthesis of unsaturated fatty acids, linoleic aciFrontiers in pharmacology1056078https://www.ebi.ac.uk/biostudies/studies/S-EPMC9708729biostudies-literatureYangyinqingfei decoction attenuates PM_2.5-induced lung injury by enhancing arachidonic acid metabolism.PMC9708729Wang QChu DTang CZhou YTang YZhou JfalseYangyinqingfei decoction attenuates PM_2.5-induced lung injury by enhancing arachidonic acid metabolism.Yangyinqingfei Decoction (YYQFD), a traditional Chinese prescription, is well known in the treatment of diphtheria and lung-related diseases in clinic. However, whether it can be used to block the lung injury caused by air pollutant remains unclear. In the present study, the effect of YYQFD was addressed using a PM_2.5-induced lung injury mice model. It was shown that YYQFD significantly improved pulmonary functions of mice exposed to PM_2.5, the levels of IL-6, TNF-α and MDA were decreased while SOD levels were increased in serum and bronchoalveolar fluid. The potential mechanism of YYQFD was then delved using metabolomic and proteomic techniques. The protein-metabolite joint analysis showed that YYQFD regulated the biosynthesis of unsaturated fatty acids, linoleic aci2022-01-01T00:00:00Z20222025-04-21T23:30:03.802Z2025-04-21T23:30:03.802ZS-EPMC97087293646703010.3389/fphar.2022.1056078