{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nankabirwa JI"],"funding":["FIC NIH HHS","NIAID NIH HHS"],"pagination":["1028-1035"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9709029"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(5)"],"pubmed_abstract":["Highly effective vector control can reduce malaria burden significantly, but individuals with parasitemia provide a potential reservoir for onward transmission. We performed an empirical, non-parametric simulation based on cohort data from Tororo District, Uganda-an area with historically high but recently reduced malaria transmission-to estimate the effects of mass drug administration (MDA) and test-and-treat on parasite prevalence. We estimate that a single round of MDA would have accelerated declines in parasite prevalence dramatically over 2 years (cumulative parasite prevalence ratio [PPR], 0.34). This decline was mostly during the first year of administration (PPR, 0.23) and waned by 23 months (PPR, 0.74). Test-and-treat using a highly sensitive diagnostic had nearly the same effect as MDA at 1 year (PPR, 0.27) and required many fewer treatments. The impact of test-and-treat using a standard diagnostic was modest (PPR, 0.58 at 1 year). Our analysis suggests that in areas experiencing a dramatic reduction in malaria prevalence, MDA or test-and-treat with a highly sensitive diagnostic may be an effective way of reducing or eliminating the infectious reservoir temporarily. However, for sustained benefits, repeated rounds of the intervention or additional interventions are required."],"journal":["The American journal of tropical medicine and hygiene"],"pubmed_title":["Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir."],"pmcid":["PMC9709029"],"funding_grant_id":["K23 AI076614","U19 AI089674","K24 AI144048","D43 TW010526","K23 AI166009","K43 TW010365"],"pubmed_authors":["Greenhouse B","Rek J","Olwoch P","Arinaitwe E","Dorsey G","Briggs J","Rodriguez-Barraquer I","Kamya MR","Smith DL","Rosenthal PJ","Nankabirwa JI"],"additional_accession":[]},"is_claimable":false,"name":"Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir.","description":"Highly effective vector control can reduce malaria burden significantly, but individuals with parasitemia provide a potential reservoir for onward transmission. We performed an empirical, non-parametric simulation based on cohort data from Tororo District, Uganda-an area with historically high but recently reduced malaria transmission-to estimate the effects of mass drug administration (MDA) and test-and-treat on parasite prevalence. We estimate that a single round of MDA would have accelerated declines in parasite prevalence dramatically over 2 years (cumulative parasite prevalence ratio [PPR], 0.34). This decline was mostly during the first year of administration (PPR, 0.23) and waned by 23 months (PPR, 0.74). Test-and-treat using a highly sensitive diagnostic had nearly the same effect as MDA at 1 year (PPR, 0.27) and required many fewer treatments. The impact of test-and-treat using a standard diagnostic was modest (PPR, 0.58 at 1 year). Our analysis suggests that in areas experiencing a dramatic reduction in malaria prevalence, MDA or test-and-treat with a highly sensitive diagnostic may be an effective way of reducing or eliminating the infectious reservoir temporarily. However, for sustained benefits, repeated rounds of the intervention or additional interventions are required.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2024-11-19T20:43:40.96Z","creation":"2024-11-19T20:43:40.96Z"},"accession":"S-EPMC9709029","cross_references":{"pubmed":["36191870"],"doi":["10.4269/ajtmh.21-0953"]}}