{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kameda T"],"funding":["MEXT | Japan Society for the Promotion of Science","Japan Agency for Medical Research and Development"],"pagination":["1309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9709164"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(1)"],"pubmed_abstract":["Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-κB signaling, such as CARD11, are detected in about 90% of patients. Utilizing mice expressing CD4<sup>+</sup> T cell-specific CARD11(E626K) and/or CD4<sup>+</sup> T cell-specific HBZ, namely CARD11(E626K)<sup>CD4-Cre</sup> mice, HBZ transgenic (Tg) mice, and CARD11(E626K)<sup>CD4-Cre</sup>;HBZ Tg double transgenic mice, we clarify these genes' pathogenetic effects. CARD11(E626K)<sup>CD4-Cre</sup> and HBZ Tg mice exhibit lymphocytic invasion to many organs, including the lungs, and double transgenic mice develop lymphoproliferative disease and increase CD4<sup>+</sup> "],"journal":["Communications biology"],"pubmed_title":["CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma."],"pmcid":["PMC9709164"],"funding_grant_id":["17K09931","20ck0106538h0001","20ck0106409h0003"],"pubmed_authors":["Kamiunten A","Tahira Y","Matsuda T","Koya J","Kitai Y","Kataoka K","Yokomizo-Nakano T","Kubota S","Kogure Y","Kameda T","Sugiyama M","Shide K","Marutsuka K","Ohshima T","Morishita D","Sashida G","Hidaka T","Kubuki Y","Ogawa S","Sekine M","Akizuki K","Shimoda K","Yoda A"],"additional_accession":[]},"is_claimable":false,"name":"CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma.","description":"Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-κB signaling, such as CARD11, are detected in about 90% of patients. Utilizing mice expressing CD4<sup>+</sup> T cell-specific CARD11(E626K) and/or CD4<sup>+</sup> T cell-specific HBZ, namely CARD11(E626K)<sup>CD4-Cre</sup> mice, HBZ transgenic (Tg) mice, and CARD11(E626K)<sup>CD4-Cre</sup>;HBZ Tg double transgenic mice, we clarify these genes' pathogenetic effects. CARD11(E626K)<sup>CD4-Cre</sup> and HBZ Tg mice exhibit lymphocytic invasion to many organs, including the lungs, and double transgenic mice develop lymphoproliferative disease and increase CD4<sup>+</sup> ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-03T21:31:04.684Z","creation":"2025-04-03T21:31:04.684Z"},"accession":"S-EPMC9709164","cross_references":{"pubmed":["36446869"],"doi":["10.1038/s42003-022-04284-x"]}}