{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sharma R"],"funding":["National Natural Science Foundation of China"],"pagination":["1063118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9709420"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["<i>Trikatu Churna</i> (<i>TC</i>) comprising <i>Zingiber officinale</i> rhizome, <i>Piper longum</i>, and <i>Piper nigrum</i> fruit, is effective in treating liver diseases and has high nutraceutical values. However, the efficacy of <i>TC</i> in treating alcoholic liver disease (ALD) and its mechanism remain largely unknown. This study evaluated the hepatoprotective effects of different doses of <i>TC</i> as well as to identify the bioactive components and determine their mechanism of action against ethanol-induced ALD. A compound-target network analysis model of <i>TC</i> was established to identify its potential bioactive compounds and pathways that might regulate its hepatoprotective effects. Further, <i>in-vivo</i> studies were performed to validate the potential of <i>TC</i> (200 mg/k"],"journal":["Frontiers in nutrition"],"pubmed_title":["Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and <i>in vivo</i> validation."],"pmcid":["PMC9709420"],"funding_grant_id":["32070671"],"pubmed_authors":["Jadhav M","Sharma R","Gundamaraju R","AlAsmari AF","Ali N","Rauf A","Shen B","Choudhary N","Kumar A","Singla RK"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and <i>in vivo</i> validation.","description":"<i>Trikatu Churna</i> (<i>TC</i>) comprising <i>Zingiber officinale</i> rhizome, <i>Piper longum</i>, and <i>Piper nigrum</i> fruit, is effective in treating liver diseases and has high nutraceutical values. However, the efficacy of <i>TC</i> in treating alcoholic liver disease (ALD) and its mechanism remain largely unknown. This study evaluated the hepatoprotective effects of different doses of <i>TC</i> as well as to identify the bioactive components and determine their mechanism of action against ethanol-induced ALD. A compound-target network analysis model of <i>TC</i> was established to identify its potential bioactive compounds and pathways that might regulate its hepatoprotective effects. Further, <i>in-vivo</i> studies were performed to validate the potential of <i>TC</i> (200 mg/k","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T11:37:31.692Z","creation":"2024-11-20T21:36:18.708Z"},"accession":"S-EPMC9709420","cross_references":{"pubmed":["36466417"],"doi":["10.3389/fnut.2022.1063118"]}}