{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(12)"],"submitter":["Weynand J"],"pubmed_abstract":["Herein we report on the study of novel dinuclear ruthenium(ii) complexes designed to target and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently generate guanine radical cation sites as photo-oxidation products. The compounds also display efficient cell penetration with localization to the nucleus and show strong photocytotoxicity toward osteosarcoma cells. Thanks to a microscopic-based telomere dysfunction assay, which allows the direct visualization of DNA damage in cells, we brought the first evidence of forming photo-oxidative damage at telomeres in cellulo. This emphasizes interesting prospects for the development of future cancer phototherapies."],"journal":["RSC chemical biology"],"pagination":["1375-1379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9709782"],"repository":["biostudies-literature"],"pubmed_title":["Photo-induced telomeric DNA damage in human cancer cells."],"pmcid":["PMC9709782"],"pubmed_authors":["Gillard M","Le Berre G","Episkopou H","Dejeu J","Weynand J","Elias B","Decottignies A","Defrancq E"],"additional_accession":[]},"is_claimable":false,"name":"Photo-induced telomeric DNA damage in human cancer cells.","description":"Herein we report on the study of novel dinuclear ruthenium(ii) complexes designed to target and to photo-react with G-quadruplex telomeric DNA. Upon irradiation, complexes efficiently generate guanine radical cation sites as photo-oxidation products. The compounds also display efficient cell penetration with localization to the nucleus and show strong photocytotoxicity toward osteosarcoma cells. Thanks to a microscopic-based telomere dysfunction assay, which allows the direct visualization of DNA damage in cells, we brought the first evidence of forming photo-oxidative damage at telomeres in cellulo. This emphasizes interesting prospects for the development of future cancer phototherapies.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T17:13:45.931Z","creation":"2025-04-07T04:46:38.806Z"},"accession":"S-EPMC9709782","cross_references":{"pubmed":["36544575"],"doi":["10.1039/d2cb00192f"]}}