{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["47(6)"],"submitter":["Jaspers-Fayer F"],"pubmed_abstract":["<h4>Background</h4>Pediatric obsessive-compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD.<h4>Methods</h4>Before and after a symptom provocation task, youth with OCD (<i>n</i> = 23; 9 boys; mean age ± standard deviation 15.1 ± 2.6 years) and matched healthy controls (<i>n</i> = 23) completed the Tower of London task during functional MRI scanning.<h4>Results</h4>During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group ×"],"journal":["Journal of psychiatry & neuroscience : JPN"],"pagination":["E409-E420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9710544"],"repository":["biostudies-literature"],"pubmed_title":["An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder."],"pmcid":["PMC9710544"],"pubmed_authors":["Stewart SE","Lin B","de Wit S","Thorsen AL","van den Heuvel OA","Jaspers-Fayer F","Negreiros J","Best JR","Ellwyn R","Chan E","Lin SY"],"additional_accession":[]},"is_claimable":false,"name":"An fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.","description":"<h4>Background</h4>Pediatric obsessive-compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD.<h4>Methods</h4>Before and after a symptom provocation task, youth with OCD (<i>n</i> = 23; 9 boys; mean age ± standard deviation 15.1 ± 2.6 years) and matched healthy controls (<i>n</i> = 23) completed the Tower of London task during functional MRI scanning.<h4>Results</h4>During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group ×","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov-Dec","modification":"2025-04-19T05:10:38.493Z","creation":"2025-04-19T05:10:38.493Z"},"accession":"S-EPMC9710544","cross_references":{"pubmed":["36414328"],"doi":["10.1503/jpn.220064"]}}