biostudies-literatureUnknown47(6)Jaspers-Fayer F<h4>Background</h4>Pediatric obsessive-compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD.<h4>Methods</h4>Before and after a symptom provocation task, youth with OCD (<i>n</i> = 23; 9 boys; mean age ± standard deviation 15.1 ± 2.6 years) and matched healthy controls (<i>n</i> = 23) completed the Tower of London task during functional MRI scanning.<h4>Results</h4>During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group ×Journal of psychiatry & neuroscience : JPNE409-E420https://www.ebi.ac.uk/biostudies/studies/S-EPMC9710544biostudies-literatureAn fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.PMC9710544Stewart SELin Bde Wit SThorsen ALvan den Heuvel OAJaspers-Fayer FNegreiros JBest JREllwyn RChan ELin SYfalseAn fMRI study of cognitive planning before and after symptom provocation in pediatric obsessive-compulsive disorder.<h4>Background</h4>Pediatric obsessive-compulsive disorder (OCD) has been associated with poorer planning in laboratory, school and home settings. It is unclear whether this impairment is a standalone cognitive issue or the result of OCD symptoms. No study has examined the influence of provoked distress on planning performance and neural correlates in pediatric OCD.<h4>Methods</h4>Before and after a symptom provocation task, youth with OCD (<i>n</i> = 23; 9 boys; mean age ± standard deviation 15.1 ± 2.6 years) and matched healthy controls (<i>n</i> = 23) completed the Tower of London task during functional MRI scanning.<h4>Results</h4>During planning, participants with OCD recruited the left superior frontal gyrus to a greater extent than healthy controls after symptom provocation (group ×2022-01-01T00:00:00Z2022 Nov-Dec2025-04-19T05:10:38.493Z2025-04-19T05:10:38.493ZS-EPMC97105443641432810.1503/jpn.220064