{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(11)"],"submitter":["Biesbroek G"],"funding":["Anonymous donor through the AMC foundation","Dutch Foundation Kind & Handicap","#wakeuptocorona crowdfund initiative of the Bontius Stichting","Leiden University Fund"],"pubmed_abstract":["Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3+CD4+ T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-γ associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines."],"journal":["PloS one"],"pagination":["e0266336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9710748"],"repository":["biostudies-literature"],"pubmed_title":["Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study."],"pmcid":["PMC9710748"],"pubmed_authors":["Ottenhoff THM","Biesbroek G","Buddingh EP","Blink M","van der Kuip M","van den Berg JM","von Asmuth EGJ","Kuijpers TW","van Veenendaal M","Ketharanathan N","den Boer MEJ","Joosten SA","Scherpbier H","Boele van Hensbroek M","Peros TE","Mooij MG","Brackel CLH","van Houten MA","Schonenberg-Meinema D","Jansen MHA","Gruppen MP","van Meijgaarden KE","Tutu van Furth AM","van Stijn D","Kapitein B","Landman GW","Zaaijer HL","Hombrink P","Kuipers IM","van der Zee CW"],"additional_accession":[]},"is_claimable":false,"name":"Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study.","description":"Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3+CD4+ T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-γ associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T22:15:17.068Z","creation":"2025-04-04T22:15:17.068Z"},"accession":"S-EPMC9710748","cross_references":{"pubmed":["36449533"],"doi":["10.1371/journal.pone.0266336"]}}