{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garvey AA"],"funding":["Science Foundation Ireland","National Children&amp;apos;s Research Centre, Ireland. Grant Number D/18/6","Health Research Board"],"pagination":["1622-1629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712087"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(12)"],"pubmed_abstract":["<h4>Objective</h4>To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).<h4>Study design</h4>Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group.<h4>Results</h4>Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR.<h4>Conclusion</h4>TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted."],"journal":["Journal of perinatology : official journal of the California Perinatal Association"],"pubmed_title":["Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy."],"pmcid":["PMC9712087"],"funding_grant_id":["SFI/RC/2272","CDA2018-008"],"pubmed_authors":["Boylan GB","Murray DM","Pavel AM","O'Neill R","Livingstone V","Finn D","Dempsey EM","Garvey AA"],"additional_accession":[]},"is_claimable":false,"name":"Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy.","description":"<h4>Objective</h4>To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).<h4>Study design</h4>Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group.<h4>Results</h4>Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR.<h4>Conclusion</h4>TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T13:46:39.31Z","creation":"2025-04-04T13:46:39.31Z"},"accession":"S-EPMC9712087","cross_references":{"pubmed":["36056257"],"doi":["10.1038/s41372-022-01495-2"]}}