biostudies-literatureGarvey AAScience Foundation IrelandNational Children&amp;apos;s Research Centre, Ireland. Grant Number D/18/6Health Research Board1622-1629https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712087biostudies-literatureUnknown42(12)<h4>Objective</h4>To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).<h4>Study design</h4>Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group.<h4>Results</h4>Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR.<h4>Conclusion</h4>TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.Journal of perinatology : official journal of the California Perinatal AssociationNon-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy.PMC9712087SFI/RC/2272CDA2018-008Boylan GBMurray DMPavel AMO'Neill RLivingstone VFinn DDempsey EMGarvey AAfalseNon-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy.<h4>Objective</h4>To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE).<h4>Study design</h4>Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group.<h4>Results</h4>Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR.<h4>Conclusion</h4>TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.2022-01-01T00:00:00Z2022 Dec2025-04-04T13:46:39.31Z2025-04-04T13:46:39.31ZS-EPMC97120873605625710.1038/s41372-022-01495-2