biostudies-literatureUnknown8(12)Bechara RAnaerobic digestion is a sustainable organic waste treatment technique with energy recovery via biogas generation. This work presents a novel Aspen Plus ADM1-based flowsheet for this process. Three reactor segments were chosen: stoichiometric for the hydrolysis step, kinetic for acido-aceto-methanogenesis, and equilibrium for hydrogenotrophic methane production. Selected parameters- conversion ratios, kinetic pre-exponent and inhibitor factors- were controlled to best fit model and experimental results. The parity plot fitting had an R² = 0.999, a slope of 1.0058 and an intercept of -0.8651. Obtained parameter values stressed the importance of inhibitions, and simulation results showcased the bell-shaped curve for acetic and volatile fatty acid reduction. The model was used for a subsequent sensitivity analysis as well as an optimization runs, leading to a 50% higher methane production ratio. The proposed model presents itself as a significant contribution for optimal anaerobic digestion process design.Heliyone11793https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712131biostudies-literatureImprovements to the ADM1 based Process Simulation Model: Reaction segregation, parameter estimation and process optimization.PMC9712131Bechara RfalseImprovements to the ADM1 based Process Simulation Model: Reaction segregation, parameter estimation and process optimization.Anaerobic digestion is a sustainable organic waste treatment technique with energy recovery via biogas generation. This work presents a novel Aspen Plus ADM1-based flowsheet for this process. Three reactor segments were chosen: stoichiometric for the hydrolysis step, kinetic for acido-aceto-methanogenesis, and equilibrium for hydrogenotrophic methane production. Selected parameters- conversion ratios, kinetic pre-exponent and inhibitor factors- were controlled to best fit model and experimental results. The parity plot fitting had an R² = 0.999, a slope of 1.0058 and an intercept of -0.8651. Obtained parameter values stressed the importance of inhibitions, and simulation results showcased the bell-shaped curve for acetic and volatile fatty acid reduction. The model was used for a subsequent sensitivity analysis as well as an optimization runs, leading to a 50% higher methane production ratio. The proposed model presents itself as a significant contribution for optimal anaerobic digestion process design.2022-01-01T00:00:00Z2022 Dec2025-04-04T23:44:55.762Z2025-04-04T23:44:55.762ZS-EPMC97121313646657010.1016/j.heliyon.2022.e11793