{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johnstone BA"],"funding":["State Government of Victoria","NIAID NIH HHS","National Health and Medical Research Council","National Institutes of Health","NIH HHS","Australian Research Council"],"pagination":["1169-1179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712165"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(12)"],"pubmed_abstract":["The cholesterol-dependent cytolysins (CDCs) are a major family of bacterial pore-forming proteins secreted as virulence factors by Gram-positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol-rich membranes, where they oligomerize into ring-shaped pores of more than 30 monomers. Understanding the details of the steps the toxin undergoes in converting from monomer to a membrane-spanning pore is a continuing challenge. In this review we summarize what we know about CDCs and highlight the remaining outstanding questions that require answers to obtain a complete picture of how these toxins kill cells."],"journal":["IUBMB life"],"pubmed_title":["Cholesterol-dependent cytolysins: The outstanding questions."],"pmcid":["PMC9712165"],"funding_grant_id":["R01 AI037657","APP1194263","R37 AI037657","DP200102871","R37-AI037657","IC200100052","DP160101874","R37‐AI037657"],"pubmed_authors":["Christie MP","Walsh JC","Bocking T","McGuiness C","Johnstone BA","Parker MW","Tweten RK","Joseph R","Morton CJ"],"additional_accession":[]},"is_claimable":false,"name":"Cholesterol-dependent cytolysins: The outstanding questions.","description":"The cholesterol-dependent cytolysins (CDCs) are a major family of bacterial pore-forming proteins secreted as virulence factors by Gram-positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol-rich membranes, where they oligomerize into ring-shaped pores of more than 30 monomers. Understanding the details of the steps the toxin undergoes in converting from monomer to a membrane-spanning pore is a continuing challenge. In this review we summarize what we know about CDCs and highlight the remaining outstanding questions that require answers to obtain a complete picture of how these toxins kill cells.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-05-29T21:47:22.779Z","creation":"2025-02-19T01:17:31.095Z"},"accession":"S-EPMC9712165","cross_references":{"pubmed":["35836358"],"doi":["10.1002/iub.2661"]}}