{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Frenzel S"],"funding":["NIA NIH HHS","NHLBI NIH HHS","NINDS NIH HHS"],"pagination":["1073-1083"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712227"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(3)"],"pubmed_abstract":["<h4>Background</h4>Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.<h4>Objective</h4>To study the cross-sectional associations of pulmonary function with structural brain variables.<h4>Methods</h4>Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities"],"journal":["Journal of Alzheimer's disease : JAD"],"pubmed_title":["Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis."],"pmcid":["PMC9712227"],"funding_grant_id":["R01 AG054076","P30 AG066546","RF1 AG059421","R01 NS017950","R01 HL105756"],"pubmed_authors":["Vernooij MW","Melo van Lent D","Psaty BM","Volzke H","Yaqub A","Lopez OL","Gudnason V","Gireud-Goss M","Satizabal CL","Brusselle GGO","Wiggins KL","Simino J","Ikram MA","Grabe HJ","Bulow R","O'Connor G","Ewert R","Vasan RS","Knopman DS","Talluri R","London SJ","Bartz TM","Gharib SA","Mosley T","Longstreth WT","Seshadri S","Bis JC","Frenzel S","Ghosh S","Beiser AS","O'Donnell A","Gottesman RF","Yu B","Wolters FJ","DeCarli CS","Launer LJ","Sigurdsson S","Shrestha S","Stubbe B","Gudmundsson EF"],"additional_accession":[]},"is_claimable":false,"name":"Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.","description":"<h4>Background</h4>Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.<h4>Objective</h4>To study the cross-sectional associations of pulmonary function with structural brain variables.<h4>Methods</h4>Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-16T22:32:57.675Z","creation":"2025-04-06T11:25:10.921Z"},"accession":"S-EPMC9712227","cross_references":{"pubmed":["36213999"],"doi":["10.3233/JAD-220667"]}}