biostudies-literatureFrenzel SNIA NIH HHSNHLBI NIH HHSNINDS NIH HHS1073-1083https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712227biostudies-literatureUnknown90(3)<h4>Background</h4>Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.<h4>Objective</h4>To study the cross-sectional associations of pulmonary function with structural brain variables.<h4>Methods</h4>Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensitiesJournal of Alzheimer's disease : JADAssociations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.PMC9712227R01 AG054076P30 AG066546RF1 AG059421R01 NS017950R01 HL105756Vernooij MWMelo van Lent DPsaty BMVolzke HYaqub ALopez OLGudnason VGireud-Goss MSatizabal CLBrusselle GGOWiggins KLSimino JIkram MAGrabe HJBulow RO'Connor GEwert RVasan RSKnopman DSTalluri RLondon SJBartz TMGharib SAMosley TLongstreth WTSeshadri SBis JCFrenzel SGhosh SBeiser ASO'Donnell AGottesman RFYu BWolters FJDeCarli CSLauner LJSigurdsson SShrestha SStubbe BGudmundsson EFfalseAssociations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.<h4>Background</h4>Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.<h4>Objective</h4>To study the cross-sectional associations of pulmonary function with structural brain variables.<h4>Methods</h4>Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities2022-01-01T00:00:00Z20222026-07-16T22:32:57.675Z2025-04-06T11:25:10.921ZS-EPMC97122273621399910.3233/JAD-220667