{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gorick CM"],"funding":["National Institute of Neurological Disorders and Stroke","NIBIB NIH HHS","National Institute for Health Research (NIHR)","National Institutes of Health Office of the Director","NINDS NIH HHS","NCI NIH HHS","National Institutes of Health","National Institute of Biomedical Imaging and Bioengineering","NIH HHS"],"pagination":["114583"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712235"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["191"],"pubmed_abstract":["The blood brain barrier (BBB) plays a critically important role in the regulation of central nervous system (CNS) homeostasis, but also represents a major limitation to treatments of brain pathologies. In recent years, focused ultrasound (FUS) in conjunction with gas-filled microbubble contrast agents has emerged as a powerful tool for transiently and non-invasively disrupting the BBB in a targeted and image-guided manner, allowing for localized delivery of drugs, genes, or other therapeutic agents. Beyond the delivery of known therapeutics, FUS-mediated BBB opening also demonstrates the potential for use in neuromodulation and the stimulation of a range of cell- and tissue-level physiological responses that may prove beneficial in disease contexts. Clinical trials investigating the safety and efficacy of FUS-mediated BBB opening are well underway, and offer promising non-surgical approaches to treatment of devastating pathologies. This article reviews a range of pre-clinical and clinical studies demonstrating the tremendous potential of FUS to fundamentally change the paradigm of treatment for CNS diseases."],"journal":["Advanced drug delivery reviews"],"pubmed_title":["Applications of focused ultrasound-mediated blood-brain barrier opening."],"pmcid":["PMC9712235"],"funding_grant_id":["R01EB030744","R01 EB030409","DP5 OD031846","CL-2018-02-002","R21 NS118278","T32 CA009109","R01 NS111102","R01EB030409","DP5OD031846","R01 EB030744","R21NS118278","R01NS111102"],"pubmed_authors":["Breza VR","Sheybani ND","Hoch MR","Cheng VWT","Gorick CM","Fisher DG","Tran NM","Nowak KM","Debski AC","Schwartz MR","Price RJ","Demir ZEF"],"additional_accession":[]},"is_claimable":false,"name":"Applications of focused ultrasound-mediated blood-brain barrier opening.","description":"The blood brain barrier (BBB) plays a critically important role in the regulation of central nervous system (CNS) homeostasis, but also represents a major limitation to treatments of brain pathologies. In recent years, focused ultrasound (FUS) in conjunction with gas-filled microbubble contrast agents has emerged as a powerful tool for transiently and non-invasively disrupting the BBB in a targeted and image-guided manner, allowing for localized delivery of drugs, genes, or other therapeutic agents. Beyond the delivery of known therapeutics, FUS-mediated BBB opening also demonstrates the potential for use in neuromodulation and the stimulation of a range of cell- and tissue-level physiological responses that may prove beneficial in disease contexts. Clinical trials investigating the safety and efficacy of FUS-mediated BBB opening are well underway, and offer promising non-surgical approaches to treatment of devastating pathologies. This article reviews a range of pre-clinical and clinical studies demonstrating the tremendous potential of FUS to fundamentally change the paradigm of treatment for CNS diseases.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T09:50:13.081Z","creation":"2025-02-19T01:17:39.589Z"},"accession":"S-EPMC9712235","cross_references":{"pubmed":["36272635"],"doi":["10.1016/j.addr.2022.114583"]}}