{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rasheduzzaman M"],"funding":["Chamindie Punyadeera","Mohammad Rasheduzzaman","Daniel Kolarich","Griffith University"],"pagination":["8401-8411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712327"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["414(29-30)"],"pubmed_abstract":["Glycosylation is the most common post-translational modification of proteins, and glycosylation changes at cell surfaces are frequently associated with malignant epithelia including head and neck squamous cell carcinoma (HNSCC). In HNSCC, 5-year survival remains poor, averaging around 50% globally: this is partly related to late diagnosis. Specific protein glycosylation signatures on malignant keratinocytes have promise as diagnostic and prognostic biomarkers and as therapeutic targets. Nevertheless, HNSCC-specific glycome is to date largely unknown. Herein, we tested six established HNSCC cell lines to capture the qualitative and semi-quantitative N-glycome using porous graphitized carbon liquid chromatography coupled to electrospray ionisation tandem mass spectrometry. Oligomannose-type "],"journal":["Analytical and bioanalytical chemistry"],"pubmed_title":["Head and neck cancer N-glycome traits are cell line and HPV status-dependent."],"pmcid":["PMC9712327"],"funding_grant_id":["Medical Research Future Fund (MRFF)","Cancer Australia (APP1145657)","Australian Government Research Training Program","Medical Research Council","Australian Government grant by project CE140100003","Australian Research Council Future Fellowship","National Health"],"pubmed_authors":["Dolcetti R","Murugan AVM","Kolarich D","Kenny L","Zhang X","Oliveira T","Johnson NW","Punyadeera C","Rasheduzzaman M"],"additional_accession":[]},"is_claimable":false,"name":"Head and neck cancer N-glycome traits are cell line and HPV status-dependent.","description":"Glycosylation is the most common post-translational modification of proteins, and glycosylation changes at cell surfaces are frequently associated with malignant epithelia including head and neck squamous cell carcinoma (HNSCC). In HNSCC, 5-year survival remains poor, averaging around 50% globally: this is partly related to late diagnosis. Specific protein glycosylation signatures on malignant keratinocytes have promise as diagnostic and prognostic biomarkers and as therapeutic targets. Nevertheless, HNSCC-specific glycome is to date largely unknown. Herein, we tested six established HNSCC cell lines to capture the qualitative and semi-quantitative N-glycome using porous graphitized carbon liquid chromatography coupled to electrospray ionisation tandem mass spectrometry. Oligomannose-type ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-05T02:50:37.728Z","creation":"2025-04-06T04:50:13.582Z"},"accession":"S-EPMC9712327","cross_references":{"pubmed":["36289103"],"doi":["10.1007/s00216-022-04376-x"]}}