{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saputra OA"],"funding":["Universitas Sebelas Maret"],"pagination":["20661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712501"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Controlling the premature release of hydrophobic drugs like quercetin over physiological conditions remains a challenge motivating the development of smart and responsive drug carriers in recent years. This present work reported a surface modification of mesoporous silica nanoparticles (MSN) by a functional compound having both amines (as a positively charged group) and carboxylic (negatively charged group), namely 4-((2-aminoethyl)amino)-4-oxobut-2-enoic acid (AmEA) prepared via simple mechanochemistry approach. The impact of MSN surface modification on physical, textural, and morphological features was evaluated by TGA, N<sub>2</sub> adsorption-desorption, PSA-zeta, SEM, and TEM. The BET surface area of AmEA-modified MSN (MSN-AmEA) was found to be 858.41 m<sup>2</sup> g<sup>-1</sup> with a pore size of 2.69 nm which could accommodate a high concentration of quercetin 118% higher than MSN. In addition, the colloidal stability of MSN-AmEA was greatly improved as indicated by high zeta potential especially at pH 4 compared to MSN. In contrast to MSN, MSN-AmEA has better in controlling quercetin release triggered by pH, thanks to the presence of the functional groups that have a pose-sensitive interaction hence it may fully control the quercetin release, as elaborated by the DFT study. Therefore, the controlled release of quercetin over MSN-AmEA verified its capability of acting as a smart drug delivery system."],"journal":["Scientific reports"],"pubmed_title":["Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli."],"pmcid":["PMC9712501"],"funding_grant_id":["514/UN27.21/HK/2020"],"pubmed_authors":["Mukti RR","Lestari WW","Lestari WA","Martien R","Sugiura T","Wibowo FR","Saputra OA","Kurniansyah V"],"additional_accession":[]},"is_claimable":false,"name":"Organically surface engineered mesoporous silica nanoparticles control the release of quercetin by pH stimuli.","description":"Controlling the premature release of hydrophobic drugs like quercetin over physiological conditions remains a challenge motivating the development of smart and responsive drug carriers in recent years. This present work reported a surface modification of mesoporous silica nanoparticles (MSN) by a functional compound having both amines (as a positively charged group) and carboxylic (negatively charged group), namely 4-((2-aminoethyl)amino)-4-oxobut-2-enoic acid (AmEA) prepared via simple mechanochemistry approach. The impact of MSN surface modification on physical, textural, and morphological features was evaluated by TGA, N<sub>2</sub> adsorption-desorption, PSA-zeta, SEM, and TEM. The BET surface area of AmEA-modified MSN (MSN-AmEA) was found to be 858.41 m<sup>2</sup> g<sup>-1</sup> with a pore size of 2.69 nm which could accommodate a high concentration of quercetin 118% higher than MSN. In addition, the colloidal stability of MSN-AmEA was greatly improved as indicated by high zeta potential especially at pH 4 compared to MSN. In contrast to MSN, MSN-AmEA has better in controlling quercetin release triggered by pH, thanks to the presence of the functional groups that have a pose-sensitive interaction hence it may fully control the quercetin release, as elaborated by the DFT study. Therefore, the controlled release of quercetin over MSN-AmEA verified its capability of acting as a smart drug delivery system.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T12:33:34.823Z","creation":"2025-04-06T14:01:28.688Z"},"accession":"S-EPMC9712501","cross_references":{"pubmed":["36450792"],"doi":["10.1038/s41598-022-25095-4"]}}