{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen W"],"funding":["Natural Science Foundation of Zhejiang Province","National Natural Science Foundation of China"],"pagination":["105644"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(12)"],"pubmed_abstract":["Linezolid resistance has represented a global concern with its wide dissemination among nosocomial pathogens in recent years. One hundred and two linezolid-resistant <i>Staphylococcus capitis</i> (LRSC) were constantly isolated from 2011 to 2021, which demonstrated single clonal dissemination in a Chinese tertiary hospital. A structurally similar <i>cfr</i>-carrying plasmid was identified among 90 isolates. A chromosomal <i>cfr</i> was located beside a Tn<i>4001</i>-like transposon and IS<i>Enfa4</i> in one strain (LR95). The loss of <i>cfr</i>-carrying plasmid was observed in 11 isolates and the <i>in vitro</i> passage experiments. Conjugation experiments demonstrated the horizontal transferability of the <i>cfr</i>-carrying plasmid into <i>Staphylococcus aureus</i> RN4220. Both <i>cfr</i>-positive LRSC and <i>S. aureus</i> showed no significant differences in growth rates, while only the former displayed competition defect, suggesting this plasmid imposed a certain fitness cost on LRSC. Hence, ongoing measurements are supposed to be adopted to control the spread of these antimicrobial-resistant bacteria."],"journal":["iScience"],"pubmed_title":["An 11-year linezolid-resistant <i>Staphylococcus capitis</i> clone dissemination with a similar <i>cfr</i>-carrying plasmid in China."],"pmcid":["PMC9712682"],"funding_grant_id":["LY22H200001","81971988"],"pubmed_authors":["Chen J","Cai J","Zhang R","Shen W"],"additional_accession":[]},"is_claimable":false,"name":"An 11-year linezolid-resistant <i>Staphylococcus capitis</i> clone dissemination with a similar <i>cfr</i>-carrying plasmid in China.","description":"Linezolid resistance has represented a global concern with its wide dissemination among nosocomial pathogens in recent years. One hundred and two linezolid-resistant <i>Staphylococcus capitis</i> (LRSC) were constantly isolated from 2011 to 2021, which demonstrated single clonal dissemination in a Chinese tertiary hospital. A structurally similar <i>cfr</i>-carrying plasmid was identified among 90 isolates. A chromosomal <i>cfr</i> was located beside a Tn<i>4001</i>-like transposon and IS<i>Enfa4</i> in one strain (LR95). The loss of <i>cfr</i>-carrying plasmid was observed in 11 isolates and the <i>in vitro</i> passage experiments. Conjugation experiments demonstrated the horizontal transferability of the <i>cfr</i>-carrying plasmid into <i>Staphylococcus aureus</i> RN4220. Both <i>cfr</i>-positive LRSC and <i>S. aureus</i> showed no significant differences in growth rates, while only the former displayed competition defect, suggesting this plasmid imposed a certain fitness cost on LRSC. Hence, ongoing measurements are supposed to be adopted to control the spread of these antimicrobial-resistant bacteria.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-21T03:16:42.022Z","creation":"2025-02-19T04:14:58.335Z"},"accession":"S-EPMC9712682","cross_references":{"pubmed":["36465119"],"doi":["10.1016/j.isci.2022.105644"]}}