biostudies-literatureUnknown5(1)Marcellin F<h4>Background & aims</h4>A growing literature shows an improvement of chronic hepatitis C virus (HCV)-related depression after successful treatment with direct-acting antivirals. However, depression after HCV cure remains insufficiently documented in people living with HIV (PLWH) and HCV, a population with specific mental health challenges. This study aimed to (i) document the prevalence of moderate-to-severe depression (PHQ-9 score ≥10) across different age classes in HCV-cured PLWH; (ii) identify associated socio-behavioral correlates.<h4>Methods</h4>Descriptive analyses were performed on data collected during a cross-sectional survey (February 2018 - May 2019) nested in a prospective, multicenter cohort of individuals living with HIV and HCV (ANRS CO13 HEPAVIH). Socio-behavioral correlJHEP reports : innovation in hepatology100614https://www.ebi.ac.uk/biostudies/studies/S-EPMC9712994biostudies-literatureDepressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH).PMC9712994Bernard NMartins CRodallec ANaqvi AMercie PChambrin VDevoto JPGervais AZucman DSow AChalal LTouam FHall NBayoud RLevy YParlier SZaegel OKoffi JWendum DMorlat PAutran BZoulim FFisher PParadis VLacombe KLouisin CVittecocq DBuisson MDuong Van Huyen MNicot FJAmiel CGirard PMJoulie ADeback CClinical Centers (ward: participating physicians)Radenne SBoue FGuillochon QMahy SBonnet FBani-Sadr FGerber AValantin MAPeytavin GBicart-See AThoirain-Galvan VBouchaud OGatey CCarrieri PPlatterier PGillet SMelica GKatlama CInfectiologieThilbaut PAbgrall SBioulac-Sage PFarfour EPeyramond DDesvallees MDominguez SHemon CPerpoint TAdam JBatard MLLacoste DCavellec MSalmon DMajerholc CCaldato SGreib COusidhoum YCervera PLazzaro ELack PSaint-Paul MCAkel SLevier ABrollo MGantner PGilbert CBarange KTraore LMeyer LBregigeon-Ronot SUzan MTrimoulet PBiron CPartisani MBornarel DMolina JMBiron FDuvivier CReceveur MCFaure IHaudebourg JBureau-Stoltmann MDutronc HVandenhende MLascoux-Combe CCastet-Lafarie SHessamfar MSerfaty LMaylin SDi Beo VAder FCatalan PMartinez VMakhoukhi FZBlanchard EBen Rayana RChesnel CLarroquette FSpire BAugustin-Normand CMora MLascaux ASMartin APoizot-Martin ILe Cam MDuffau PBillaud ESogni PTeicher EFourati VSSelves JSicart-Payssan VPiroth LZiol MPetrov-Sanchez VDelaugerre CLelievre JDFontaine HWaldner-Combernoux AChidiac CFischer PConte VANRS CO13 HEPAVIH Study GroupBraik OSoria AZelie JHue HBottero JTumiotto CBoufassa FDauchy FBerger JLCallard PReliquet VLe-Thi TTNafissa SLourenco JLaroche HLefebvre MGaripuy DBarre TLe Baut VTamalet CViala CDequae-Merchadou LFavier MHentzien MManagement, statistical analysesBrodard VPistone TLortholary OPietri MPCroisier-Bertin DAnriamiandrisoa SCazanave CMarchou BDesclaux ASalmon Rousseau AScholtes CRitleg ASTerris BFerry TFerro-Collados MJAdda-Lievin AYazdanpanah YMebarki MSolas CViallard JFBouchez SMaynard MIwaka-Bande VQuertainmont YValour FRamier CRivoisy CSimon AKnight RBeniken DMartell CData collectionNeau DBreau SGoujard CVirologieCotte LMechain MKmiec IDupon MLambert DBedel ECacoub PGalim SBolliot COchoa APaccalin FBaazia YIvanova AOgoudjobi SRey DBenhamou YRio VAllavena CLepuil SMole MLacaze-Buzy LPertusa MCGohier SMetivier SBoutoille DTremeaux PMiailhes PCheneau CBernard-Henry CBailly FPauchard MDebreux CMalvy DRoux PAlexandre GRaffi FAmiri MAdle-Biassette Hde Mautort EMichel LBertheau PIzopet JLe Guen LBerroukeche LBellecave PCostagliola DReigadas SMarcellin FPartouche CEsterle LZaegel-Faucher OBureau MLions CP CarrieriScientific CommitteeChaix MLMonte APallier CRoustant FLe Pendeven CRouzaud CPignon CPriester MBrochier CRosenthal EFior RKrause JProtopopescu CChas JStitou HAvettand-Fenoel VNguyen YGardiennet EAumaitre HUsubillaga RBendjaballah FMelard ABoibieux APialoux GRoque AMFafi-Kremer SKhan CPellegrin JLPomes CKansau IAlric LGiordanengo VChalouni MCharlotte FWittkop LChavanet PSalmon-Ceron DfalseDepressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH).<h4>Background & aims</h4>A growing literature shows an improvement of chronic hepatitis C virus (HCV)-related depression after successful treatment with direct-acting antivirals. However, depression after HCV cure remains insufficiently documented in people living with HIV (PLWH) and HCV, a population with specific mental health challenges. This study aimed to (i) document the prevalence of moderate-to-severe depression (PHQ-9 score ≥10) across different age classes in HCV-cured PLWH; (ii) identify associated socio-behavioral correlates.<h4>Methods</h4>Descriptive analyses were performed on data collected during a cross-sectional survey (February 2018 - May 2019) nested in a prospective, multicenter cohort of individuals living with HIV and HCV (ANRS CO13 HEPAVIH). Socio-behavioral correl2023-01-01T00:00:00Z2023 Jan2025-04-05T10:34:56.091Z2025-04-05T10:34:56.091ZS-EPMC97129943646699010.1016/j.jhepr.2022.100614