{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Bin T"],"pubmed_abstract":["<h4>Background</h4>RNA-binding protein (RBP) regulates acute myeloid leukemia (AML) by participating in mRNA editing and modification. Pyroptosis also plays an immunomodulatory function in AML. Therefore, this study aimed to identify pyroptosis-related RBP genes that could predict the prognosis of AML patients.<h4>Methods</h4>AML related expression data were downloaded from the UCSC website and Gene Expression Omnibus (GEO) database. Pyroptosis-RPB-related differentially expressed genes (PRBP-DEGs) were conducted with a protein-protein interactions (PPI) network to screen out the key PRBP-DEGs, based on which a risk model was constructed by Cox analysis, and evaluated by plotting Receiver operating characteristic (ROC) curves and survival curves. Independent prognostic analysis was perform"],"journal":["Frontiers in oncology"],"pagination":["1059978"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9713014"],"repository":["biostudies-literature"],"pubmed_title":["Establishment of a risk model correlated with metabolism based on RNA-binding proteins associated with cell pyroptosis in acute myeloid leukemia."],"pmcid":["PMC9713014"],"pubmed_authors":["Liu FJ","Tang J","Lin C","Bin T","Xu XJ","Wang Y","Lin DJ","Lu B"],"additional_accession":[]},"is_claimable":false,"name":"Establishment of a risk model correlated with metabolism based on RNA-binding proteins associated with cell pyroptosis in acute myeloid leukemia.","description":"<h4>Background</h4>RNA-binding protein (RBP) regulates acute myeloid leukemia (AML) by participating in mRNA editing and modification. Pyroptosis also plays an immunomodulatory function in AML. Therefore, this study aimed to identify pyroptosis-related RBP genes that could predict the prognosis of AML patients.<h4>Methods</h4>AML related expression data were downloaded from the UCSC website and Gene Expression Omnibus (GEO) database. Pyroptosis-RPB-related differentially expressed genes (PRBP-DEGs) were conducted with a protein-protein interactions (PPI) network to screen out the key PRBP-DEGs, based on which a risk model was constructed by Cox analysis, and evaluated by plotting Receiver operating characteristic (ROC) curves and survival curves. Independent prognostic analysis was perform","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-21T03:17:22.651Z","creation":"2025-02-19T04:14:22.296Z"},"accession":"S-EPMC9713014","cross_references":{"pubmed":["36465357"],"doi":["10.3389/fonc.2022.1059978"]}}