biostudies-literatureUnknown13Needhamsen MEuropean Research CouncilMultiple Sclerosis (MS) is an autoimmune, neurological disease, commonly presenting with a relapsing-remitting form, that later converts to a secondary progressive stage, referred to as RRMS and SPMS, respectively. Early treatment slows disease progression, hence, accurate and early diagnosis is crucial. Recent advances in large-scale data processing and analysis have progressed molecular biomarker development. Here, we focus on small RNA data derived from cell-free cerebrospinal fluid (CSF), cerebrospinal fluid cells, plasma and peripheral blood mononuclear cells as well as CSF cell methylome data, from people with RRMS (n = 20), clinically/radiologically isolated syndrome (CIS/RIS, n = 2) and neurological disease controls (n = 14). We applied multiple co-inertia analysis (MCIA), an unsupFrontiers in geneticshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9713411biostudies-literatureIntegration of small RNAs from plasma and cerebrospinal fluid for classification of multiple sclerosisPMC9713411818170Needhamsen MPiket EJagodic MZheleznyakova GHagemann-Jensen MGierlich JHan YEkman DKhoonsari PfalseIntegration of small RNAs from plasma and cerebrospinal fluid for classification of multiple sclerosisMultiple Sclerosis (MS) is an autoimmune, neurological disease, commonly presenting with a relapsing-remitting form, that later converts to a secondary progressive stage, referred to as RRMS and SPMS, respectively. Early treatment slows disease progression, hence, accurate and early diagnosis is crucial. Recent advances in large-scale data processing and analysis have progressed molecular biomarker development. Here, we focus on small RNA data derived from cell-free cerebrospinal fluid (CSF), cerebrospinal fluid cells, plasma and peripheral blood mononuclear cells as well as CSF cell methylome data, from people with RRMS (n = 20), clinically/radiologically isolated syndrome (CIS/RIS, n = 2) and neurological disease controls (n = 14). We applied multiple co-inertia analysis (MCIA), an unsup2022-01-01T00:00:00Z2022 Jan2025-04-04T07:47:59.146Z2025-02-19T04:13:56.972ZS-EPMC9713411