biostudies-literatureUnknown23(1)Maddahi A<h4>Background</h4>Hypothalamus is a key region in migraine attacks. In addition, women are disproportionately affected by migraine. The calcitonin gene-related peptide (CGRP) system is an important key player in migraine pathophysiology. CGRP signaling could be a target of hormones that influence migraine. Our aim is to identify the expression of vasopressin and its receptors in the brain and in the trigeminovascular system with focus on the migraine-related regions and, furthermore, to examine the role of sex on the expression of neurohormones in the trigeminal ganglion.<h4>Methods</h4>Rat brain and trigeminal ganglia were carefully harvested, and protein and mRNA levels were analyzed by immunohistochemistry and real-time PCR, respectively.<h4>Results</h4>Vasopressin and its receptors imThe journal of headache and pain152https://www.ebi.ac.uk/biostudies/studies/S-EPMC9713967biostudies-literatureExpression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex.PMC9713967Edvinsson LMaddahi AWarfvinge KfalseExpression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex.<h4>Background</h4>Hypothalamus is a key region in migraine attacks. In addition, women are disproportionately affected by migraine. The calcitonin gene-related peptide (CGRP) system is an important key player in migraine pathophysiology. CGRP signaling could be a target of hormones that influence migraine. Our aim is to identify the expression of vasopressin and its receptors in the brain and in the trigeminovascular system with focus on the migraine-related regions and, furthermore, to examine the role of sex on the expression of neurohormones in the trigeminal ganglion.<h4>Methods</h4>Rat brain and trigeminal ganglia were carefully harvested, and protein and mRNA levels were analyzed by immunohistochemistry and real-time PCR, respectively.<h4>Results</h4>Vasopressin and its receptors im2022-01-01T00:00:00Z2022 Dec2025-04-18T22:28:31.768Z2025-02-19T04:37:51.33ZS-EPMC97139673645690210.1186/s10194-022-01524-7