{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fan HH"],"funding":["Ministry of Science and Technology, Taiwan","Taipei Medical University"],"pagination":["102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9714038"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Background</h4>yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) genes to influence bacteria-host interactions remains unclear.<h4>Methods</h4>The global transcriptomes of S. Typhimurium yqiC-deleted mutant (ΔyqiC) and its wild-type strain SL1344 after 2 h of in vitro infection with Caco-2 cells were obtained through RNA sequencing to conduct comparisons and identify major yqiC-regulated genes, particularly those involved in Salmonella pathogenicity islands (SPIs), ubiquinone and menaquinone biosynthesis, electron transportation chains (ETCs), and carbohydrate/energy metabolism. A Seahorse XFp Analyzer and assays of NADH/NAD<sup>+</sup> and H<sub>2</sub>O<sub>2</sub> wer"],"journal":["Journal of biomedical science"],"pubmed_title":["Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium."],"pmcid":["PMC9714038"],"funding_grant_id":["MOST105-2314-B-038-037-MY3","DP2-108-21121-01-O-03-01","DP2-107-21121-O-03","MOST108-2314-B-038-098-MY3"],"pubmed_authors":["Fan HH","Huang ST","Cheng HY","Chang PR","Lin PC","Huang CH","Yang LT","Fang SB","Chang WC","Chang YC"],"additional_accession":[]},"is_claimable":false,"name":"Effects of colonization-associated gene yqiC on global transcriptome, cellular respiration, and oxidative stress in Salmonella Typhimurium.","description":"<h4>Background</h4>yqiC is required for colonizing the Salmonella enterica serovar Typhimurium (S. Typhimurium) in human cells; however, how yqiC regulates nontyphoidal Salmonella (NTS) genes to influence bacteria-host interactions remains unclear.<h4>Methods</h4>The global transcriptomes of S. Typhimurium yqiC-deleted mutant (ΔyqiC) and its wild-type strain SL1344 after 2 h of in vitro infection with Caco-2 cells were obtained through RNA sequencing to conduct comparisons and identify major yqiC-regulated genes, particularly those involved in Salmonella pathogenicity islands (SPIs), ubiquinone and menaquinone biosynthesis, electron transportation chains (ETCs), and carbohydrate/energy metabolism. A Seahorse XFp Analyzer and assays of NADH/NAD<sup>+</sup> and H<sub>2</sub>O<sub>2</sub> wer","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T16:55:15.819Z","creation":"2025-04-07T04:23:01.253Z"},"accession":"S-EPMC9714038","cross_references":{"pubmed":["36457101"],"doi":["10.1186/s12929-022-00885-0"]}}