{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Ruiz M"],"funding":["Agencia Estatal de Investigación","Universidad Rey Juan Carlos"],"pagination":["502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9714087"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out "],"journal":["Journal of nanobiotechnology"],"pubmed_title":["L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria."],"pmcid":["PMC9714087"],"funding_grant_id":["CTQ2017-88642-R","PID2021-125216OB-I00","2022/00004/010"],"pubmed_authors":["Sanz R","Fernandez-Garcia P","Ruiz-Linares M","Lopez-Ruiz M","Navas F","Martinez-Erro S","Ceballos L","Fuentes MV","Giraldez I","Morales V","Ferrer-Luque CM","Garcia-Munoz RA"],"additional_accession":[]},"is_claimable":false,"name":"L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria.","description":"Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T22:28:06.812Z","creation":"2025-04-07T10:10:27.673Z"},"accession":"S-EPMC9714087","cross_references":{"pubmed":["36457046"],"doi":["10.1186/s12951-022-01714-0"]}}